Beta-blockers in new onset CHD reduce cardiac risk only post-MI
Charlotte Andersson, M.D., Ph.D., from Gentofte University Hospital in Hellerup, Denmark, and colleagues studied outcomes in 26,793 consecutive patients discharged after the first CHD event (acute coronary syndrome or coronary revascularization) between 2000 and 2008 in an integrated healthcare delivery system. Included patients did not use beta-blockers in the year before entry.
The researchers found that 19,843 of the patients initiated beta-blocker treatment within seven days of discharge from their initial CHD event. There were 6,968 patients who had an MI or died over an average of 3.7 years of follow-up. There was an adjusted hazard ratio (HR) for mortality of 0.90 with the use of beta-blockers (95 percent confidence limits, 0.84 to 0.96), and an adjusted HR for death or MI of 0.92 (95 percent confidence limits, 0.87 to 0.97). There was a significant difference in the association between beta-blockers and outcomes between patients with and without a recent MI (HR for death: 0.85 versus 1.02; P = 0.007; and HR for death or MI: 0.87 versus 1.03; P = 0.005).
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