Sleep deprivation leads to symptoms of schizophrenia

July 7, 2014, University of Bonn
Dr. Nadine Petrovsky and Professor Dr. Ulrich Ettinger from the Institute of Psychology of the University of Bonn measure the filtering function of the brain in a test subject (center) using the prepulse inhibition. Credit: (c) Volker Lannert/University of Bonn

Twenty-four hours of sleep deprivation can lead to conditions in healthy persons similar to the symptoms of schizophrenia. This discovery was made by an international team of researchers under the guidance of the University of Bonn and King's College London. The scientists point out that this effect should be investigated more closely in persons who have to work at night. In addition, sleep deprivation may serve as a model system for the development of drugs to treat psychosis. The results have now been published in The Journal of Neuroscience.

In psychosis, there is a loss of contact with reality and this is associated with hallucinations and delusions. The chronic form is referred to as schizophrenia, which likewise involves thought disorders and misperceptions. Affected persons report that they hear voices, for example. Psychoses rank among the most severe mental illnesses. An international team of researchers under the guidance of the University of Bonn has now found out that after 24 hours of sleep deprivation in healthy patients, numerous symptoms were noted which are otherwise typically attributed to psychosis or schizophrenia. "It was clear to us that a sleepless night leads to impairment in the ability to concentrate," says Prof. Dr. Ulrich Ettinger of the Cognitive Psychology Unit in the Department of Psychology at the University of Bonn. "But we were surprised at how pronounced and how wide the spectrum of schizophrenia-like symptoms was."

The scientists from the University of Bonn, King's College London (England) as well as the Department of Psychiatry and Psychotherapy of the University of Bonn Hospital examined a total of 24 healthy subjects of both genders aged 18 to 40 in the sleep laboratory of the Department of Psychology. In an initial run, the test subjects were to sleep normally in the laboratory. About one week later, they were kept awake all night with movies, conversation, games and brief walks. On the following morning, subjects were each asked about their thoughts and feelings. In addition, subjects underwent a measurement known as prepulse inhibition.

Unselected information leads to chaos in the brain

"Prepulse inhibition is a standard test to measure the filtering function of the brain," explains lead author Dr. Nadine Petrovsky from Prof. Ettinger's team. In the experiment, a loud noise is heard via headphones. As a result, the test subjects experience a startle response, which is recorded with electrodes through the contraction of facial muscles. If a weaker stimulus is emitted beforehand as a "prepulse", the startle response is lower. "The prepulse inhibition demonstrates an important function of the brain: Filters separate what is important from what is not important and prevent sensory overload," says Dr. Petrovsky.

In our subjects, this filtering function of the brain was significantly reduced following a sleepless night. "There were pronounced attention deficits, such as what typically occurs in the case of schizophrenia," reports Prof. Ettinger. "The unselected flood of information led to chaos in the brain." Following sleep deprivation, the subjects also indicated in questionnaires that they were somewhat more sensitive to light, color or brightness. Accordingly, their sense of time and sense of smell were altered and mental leaps were reported. Many of those who spent the night even had the impression of being able to read thoughts or notice altered body perception. "We did not expect that the symptoms could be so pronounced after one night spent awake," says the psychologist from the University of Bonn.

Sleep deprivation as a model system for mental illnesses

The scientists see an important potential application for their results in research for drugs to treat psychoses. "In drug development, mental disorders like these have been simulated to date in experiments using certain active substances. However, these convey the symptoms of psychoses in only a very limited manner," says Prof. Ettinger. Sleep deprivation may be a much better because the subjective symptoms and the objectively measured filter disorder are far more akin to . Of course, the sleep deprivation model is not harmful: After a good night's recovery sleep, the symptoms disappear. There is also a need for research with regard to persons who regularly have to work at night. "Whether the symptoms of gradually become weaker due to acclimatization has yet to be investigated," says the psychologist from the University of Bonn.

Explore further: Twin study links community socioeconomic deprivation to sleep duration

More information: Sleep deprivation disrupts prepulse inhibition and induces psychosis-like symptoms in healthy humans, The Journal of Neuroscience, DOI: 10.1523/JNEUROSCI.0904-14.2014

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RobertKarlStonjek
not rated yet Jul 07, 2014
"..kept awake all night with movies, conversation, games"

This kind of activity will cause fatigue. A person undergoing 12 hours of this kind of activity will be more fatigued than one doing lighter duties even if the 12 hours is from morning to evening.

Thus we have sleep deprivation + a high degree of stimulation. Contrast this to a period of intense studying, exam tests and brain training exercises. I suggest that the same effects as found above would be found with far less sleep deprivation as the brain will become fatigued much sooner.
Sinister1812
not rated yet Jul 08, 2014
What crap! I've pulled an all nighter before and never been abducted by orange leprechauns.
alfie_null
not rated yet Jul 13, 2014
A non-scientific observation: one of the most popular late night/early morning radio programs in the U.S. caters to a certain point of view: there's an evil secret body controlling the world, extra-terrestrial aliens are among us, 9/11 was actually an act committed by the U.S. government, an invisible planet is due to wreak havoc on the Earth, shadowy monstrous animals will suck the marrow from your bones, etc.

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