Ontario has one of the highest rates of IBD in the world

August 28, 2014

One in every 200 Ontarians has been diagnosed with inflammatory bowel disease (IBD), with the number of people living with the disease increasing by 64 per cent between 1999 and 2008, according to a study by researchers at the Institute for Clinical Evaluative Sciences (ICES), the Children's Hospital of Eastern Ontario (CHEO), and the Ottawa Hospital Research Institute. That puts Ontario in the 90th percentile for IBD prevalence in the world.

The study, published this week in Inflammatory Bowel Diseases, is the first and largest Canadian study of IBD – including Crohn's disease and ulcerative colitis ─ to demonstrate trends in incidence over time, and the first to review the rate of IBD in different age groups.

"The number of new diagnoses each year increased from 2,444 in 1999 to 3,342 in 2008. That means that standardized incidence has increased by an average of nearly two and a half per cent per year since the 90s," said Dr. Eric Benchimol, adjunct scientist with ICES, and pediatric gastroenterologist at CHEO.

The population-based study of all Ontario residents living with IBD from 1999-2008 found:

  • There were more than 68,000 Ontario residents with IBD living in the province in 2008.
  • The number of new cases of IBD rose significantly in children under 18, and adults 18 to 64-years-old.
  • The number of new cases of IBD was stable in elderly patients older than 65; however, the prevalence (the number of people living with IBD) rose the most during the study period in patients older than 65.
  • The elderly population with IBD represents the fastest growing group living with IBD.
  • The group with the fastest growing number of new cases are children under 10 years.

"This important study confirms, once again, that Canadians have more reasons to be concerned about Crohn's disease and than anyone else in the world," says Lindee David, CEO of Crohn's and Colitis Canada. "These are the "Canadian diseases," which place a significant burden on families and Canada's healthcare system. Dr. Benchimol's work provides further proof that we need to continue our fight to cure Crohn's and and improve the lives of children and adults living with these chronic diseases. "

According to the 2012 Impact of IBD report from Crohn's and Colitis Canada, IBD cost the Canadian health system approximately $2.8 billion in 2012, more than $11,900 per person with IBD every year.

Environmental exposure and changing demographic trends have been reported as possible causes of earlier-onset disease. For example, increasing rates of antibiotic use, birth by Caesarian section, changes in diet, or use of other medications, all may have resulted in changes to the microbiome of Ontarian children and earlier-onset disease.

"The peak number of new cases of IBD is still in young adults who are 20 to 40-years of age, but the most rapidly rising incidence is in under 10 followed by those aged 10 to 19-years. This may be due to earlier onset of disease, or better recognition and earlier diagnosis," added Benchimol.

Explore further: Flu vaccine safe for children with IBD, study shows

More information: "The changing age demographics of inflammatory bowel disease in Ontario, Canada: A population-based cohort study of epidemiology trends," appears today in Inflammatory Bowel Diseases. journals.lww.com/ibdjournal/Ab … ory_Bowel.99428.aspx

Related Stories

Flu vaccine safe for children with IBD, study shows

May 6, 2013
Influenza immunization rates in children with inflammatory bowel disease (IBD) are low despite its safety according to a new study by researchers at the Institute for Clinical Evaluative Sciences (ICES), Children's Hospital ...

Improving lymphatic function protects mice from experimental colitis

August 8, 2014
Chronic inflammatory bowel disease can be painful and debilitating. Both genetics and environment are thought to promote disease, but it is not fully understood how chronic IBD develops. Emerging evidence indicates that IBD ...

Inflammatory bowel disease raises risk of melanoma

May 20, 2013
Patients with inflammatory bowel disease (IBD) are at higher risk of melanoma, a form of skin cancer, report researchers at Mayo Clinic. Researchers found that IBD is associated with a 37 percent greater risk for the disease. ...

Research questions liver disease prevalence in IBD

April 7, 2014
Do inflammatory bowel disease (IBD) patients have a higher prevalence of clinically significant liver disease?

Study finds dramatic increase in hospitalization of US children with inflammatory bowel disease

June 25, 2013
The largest investigation to date has found a dramatic increase in the number of hospitalizations for children with inflammatory bowel disease (IBD) during the past decade in the United States.

TNF inhibitors for treatment of bowel disease not linked with increased risk of cancer

June 17, 2014
In a study that included more than 56,000 patients with inflammatory bowel disease, use of a popular class of medications known as tumor necrosis factor alpha antagonists was not associated with an increased risk of cancer ...

Recommended for you

New compound discovered in fight against inflammatory disease

September 22, 2017
A 10-year study by University of Manchester scientists for a new chemical compound that is able to block a key component in inflammatory illness has ended in success.

Asthma researchers test substance from coralberry leaves

September 14, 2017
The coralberry could offer new hope for asthmatics. Researchers at the University of Bonn have extracted an active pharmaceutical ingredient from its leaves to combat asthma, a widespread respiratory disease. In mice, it ...

Respiratory experts urge rethink of 'outdated' asthma categorisation

September 12, 2017
A group of respiratory medicine experts have called for an overhaul of how asthma and other airways diseases are categorised and treated.

New 'biologic' drug may help severe asthma

September 7, 2017
(HealthDay)—A "biologic" drug in development to treat severe asthma reduces the rate of serious attacks by about two-thirds compared to a placebo drug, according to preliminary research findings.

Songbird study shows how estrogen may stop infection-induced brain inflammation

August 31, 2017
The chemical best-known as a female reproductive hormone—estrogen—could help fight off neurodegenerative conditions and diseases in the future. Now, new research by American University neuroscience Professor Colin Saldanha ...

New insights into protein's role in inflammatory response

July 28, 2017
A protein called POP2 inhibits a key inflammatory pathway, calming the body's inflammatory response before it can become destructive, Northwestern Medicine scientists have demonstrated in mouse models.


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.