Pistachio-supplemented diet beneficial in prediabetes

Pistachio-supplemented diet beneficial in prediabetes

(HealthDay)—Pistachio consumption is associated with improvements in glucose and cardiometabolic parameters, according to a study published online Aug. 14 in Diabetes Care.

Pablo Hernández-Alonso, from the Universitari Hospital of Sant Joan de Reus in Spain, and colleagues recruited fifty-four individuals with prediabetes to consume one of two diets: a pistachio-supplemented diet (PD; including 57 g/day of pistachios) or a control diet (CD), each for four months in a crossover manner. The periods were separated by a two-week washout period.

The researchers found that after the PD diet versus the CD , there were significant decreases in fasting , insulin, and homeostasis model assessment of insulin resistance. With PD there were also significant decreases in other cardiometabolic risk markers, including fibrinogen, oxidized low-density lipoprotein, and platelet factor 4 (P < 0.05), while there was an increase in glucagon-like peptide-1. There were 9 and 6 percent decreases in interleukin-6 mRNA and resistin gene expression, respectively, after the PD (P < 0.05). A 69 percent increase was noted in SLC2A4 expression in CD (P = 0.03 for PD versus CD). During the PD there was a 78.78 percent decrease in cellular glucose uptake by lymphocytes.

"Chronic pistachio consumption is emerging as a useful nutritional strategy for the prediabetic state," the authors write.

The study was funded by American Pistachio Growers and Paramount Farms; one author disclosed being a member of the Scientific Advisory Council of the International Nut Council.

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