Cellular self-destruct program has deep roots throughout evolution

In what seems like a counter-intuitive move against survival, within animals, some cells are fated to die from the triggering of an elaborate cell death program, known as apoptosis. Now, Sakamaki et. al., have honed in on understanding the evolution of caspase-8, a key cell death initiator molecule that was first identified in humans.

By performing the most extensive evolutionary analysis of the Casp8 protein to date, they found that Casp8 activity arose very early (more than 500 MYA), and is universally conserved throughout evolution, demonstrating its functional significance throughout the animal kingdom.

"It is of great significance that the system is established in more simpler animals," said professor Sakamaki.

In addition, they were able to substitute Casp8 proteins from non-mammalian examples and trigger the same cell death pathways when placed into cultured mammalian cell experiments using a killing assay, demonstrating its universal functionality in evolution. They also demonstrate that key protein interactions between Casp8 and another called FADD are also observed across the .

Thus, the cell death toolkit is of core importance to , with occurring to eliminate unnecessary, non-functional, unhealthy, or dangerous cells from the body. "In mammals, the cells producing a death ligand and expressing death receptor (and FADD/casp8) are different, suggesting that cell-cell communication is required for this vital phenomenon," said Sakamaki.

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Oct 17, 2014
See also: http://www.ncbi.n...12810955

I wonder why evolutionary theorists think they can convince serious scientists that apoptosis is an evolutionary event. It is obviously an RNA-mediated event and RNA-directed DNA methylation links RNA-mediated cell type differentiation via amino acid substitutions that lead to increasing organismal complexity that cannot arise in the context of mutation-driven evolution.

Oct 19, 2014
Next to a "serious scientist" you are riding a unicycle wearing a clown suit, two pencils up your nose, underpants on your head and playing a gazoo.

... actually, when you aren't in a straight jacket, I'm sure that is how you dress.

Oct 19, 2014
Genome of the house fly, Musca domestica L., a global vector of diseases with adaptations to a septic environment

The olfactory and immune systems of different and of similar species are directly linked via nutrient-dependent pheromone-controlled cell type differentiation to metabolism. Experience-dependent de novo creation of olfactory receptor genes and the enzymes of metabolism make the controlled physiology of reproduction by pheromones possible in species from microbes to man.

NOM wants everyone to believe in something else. I wonder if there is a model for that. See for comparison Nutrient-dependent/pheromone-controlled adaptive evolution: a model.

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