Increased toxicity for many newly approved anticancer drugs

Increased toxicity for many newly approved anticancer drugs

(HealthDay)—Newly approved anticancer drugs that do not have a specific molecular target on cancer cells are associated with increased toxicity and the accompanying costs of management, according to research published online Sept. 29 in the Journal of Clinical Oncology.

Saroj Niraula, M.B.B.S., M.D., from CancerCare Manitoba and the University of Manitoba in Winnipeg, Canada, and colleagues examined the incidence of 12 frequent grade 3 and 4 adverse events associated with new , and the costs associated with their management. Data were included from 41 studies involving 27,539 patients and assessing 19 experimental drugs.

The researchers found that the incidence of grade 3 and 4 toxicities was lower for agents directed against a specific molecular target on than controls (median risk ratio [RR], 0.67; P = 0.22), while less-specific targeted agents were more toxic (angiogenesis inhibitors: median RR, 3.39; P < 0.001; and chemotherapeutic agents: median RR, 1.73; P < 0.001).The increased risk was observed irrespective of whether the control arm was active treatment (RR, 2.11; P < 0.001) or not (RR, 3.02; P < 0.001). For experimental drugs, the median incremental drug price was $6,000 per patient per month. Compared with drug costs, the median cost of managing toxicity was low, but for treatment with less-specific targeted agents and chemotherapies, costs for managing toxicities were higher than controls.

"Development of biomarker-driven agents should be encouraged," the authors write.

Explore further

Atypical antipsychotics up renal injury risk in seniors

More information: Abstract
Full Text (subscription or payment may be required)
Journal information: Journal of Clinical Oncology

Copyright © 2014 HealthDay. All rights reserved.

Citation: Increased toxicity for many newly approved anticancer drugs (2014, October 1) retrieved 19 September 2019 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more