Anxiety moderates amyloid-beta association with cognition

January 29, 2015
Anxiety moderates amyloid-β association with cognition

(HealthDay)—For older adults, elevated amyloid-β (Aβ) levels correlate with cognitive decline, and elevated anxiety moderates these associations, according to a study published online Jan. 28 in JAMA Psychiatry.

Robert H. Pietrzak, Ph.D., from the U.S. Department of Veterans Affairs in West Haven, Conn., and colleagues examined the correlation between Aβ status and cognitive changes in a multicenter, prospective study. Three hundred thirty-three healthy, underwent assessments at baseline and at 18, 36, and 54 months.

The researchers found that positive Aβ (Aβ+) status at baseline correlated with a significant reduction in global cognition, , language, and executive function; these correlations were moderated by elevated anxiety symptoms. Slopes of cognitive decline were significantly more pronounced in the Aβ+ high-anxiety group than in the Aβ+ low-anxiety group, with Cohen d values of 0.78, 0.54, 0.51, and 0.39 for global cognition, verbal memory, language, and , respectively. The effects were independent of confounding variables such as age, educational level, APOE genotype, subjective memory complaints, and depressive symptoms. The correlation between Aβ and was not moderated by or subjective memory complaints.

"Given that there is currently no standard antiamyloid therapy and that anxiety symptoms are amenable to treatment, these findings may help inform risk stratification and management of the preclinical phase of Alzheimer's disease," the authors write.

Two authors disclosed financial ties to Cogstate Ltd., which provided some of the cognitive tests used in this study and contributed funding to the study.

Explore further: Tracing the impact of amyloid beta in mild cognitive impairment

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Tracing the impact of amyloid beta in mild cognitive impairment

January 15, 2013
The amount of amyloid β (Aβ) in the brains of people with mild cognitive impairment (MCI) is contributing to early memory loss, and increases with severity of symptoms, finds a study in BioMed Central's open access journal ...

The benefits of a spotless mind

November 15, 2013
Alzheimer's disease is an age-related memory disorder characterized by the accumulation of clumps of the toxic amyloid-β (Aβ) protein fragment in the extracellular space around neurons in the brain. Drugs that help to 'clean ...

Understanding the molecular mechanisms underlying Alzheimer's disease

June 10, 2013
The accumulation of amyloid-β (Aβ) in the brains of Alzheimer's disease (AD) patients is known to be associated with memory loss and neuronal degeneration, but the mechanism of Aβ pathogenesis is not fully understood.

Rescuing the golgi puts brakes on Alzheimer's progression

December 5, 2014
Alzheimer's disease (AD) progresses inside the brain in a rising storm of cellular chaos as deposits of the toxic protein, amyloid-beta (Aβ), overwhelm neurons. An apparent side effect of accumulating Aβ in neurons is the ...

Persistent depression linked with cognitive decline in older patients with coronary artery disease

March 5, 2012
Persistent depression symptoms may be associated with significantly greater declines in cognitive performance in older patients with coronary artery disease who underwent cardiac catheterization, according to a study published ...

No evidence of Alzheimer's disease-associated changes in adolescents carrying genetic risk factors

April 7, 2014
Two studies published in the Journal of Alzheimer's Disease indicate that some of the pathologic changes associated with Alzheimer's disease in older individuals are not apparent in young people who carry the apolipoprotein ...

Recommended for you

Study: Tinder loving cheaters—dating app facilitates infidelity

February 23, 2018
The popular dating app Tinder is all about helping people form new relationships. But for many college-aged people, it's also helping those in relationships cheat on their romantic partners.

The 'loudness' of our thoughts affects how we judge external sounds

February 23, 2018
The "loudness" of our thoughts—or how we imagine saying something—influences how we judge the loudness of real, external sounds, a team of researchers from NYU Shanghai and NYU has found.

Looking for the origins of schizophrenia

February 23, 2018
Schizophrenia may be related to neurodevelopmental changes, including brain's inability to generate an appropriate vascular system, according to new study resulted from a partnership between the D"Or Institute for Research ...

Infants are able to learn abstract rules visually

February 22, 2018
Three-month-old babies cannot sit up or roll over, yet they are already capable of learning patterns from simply looking at the world around them, according to a recent Northwestern University study published in PLOS One.

Color of judo uniform has no effect on winning

February 22, 2018
New research on competitive judo data finds a winning bias for the athlete who is first called, regardless of the colour of their uniform. This unique study, published in Frontiers in Psychology, puts to rest the debate on ...

Antidepressants are more effective than placebo at treating acute depression in adults, concludes study

February 22, 2018
Meta-analysis of 522 trials includes the largest amount of unpublished data to date, and finds that antidepressants are more effective than placebo for short-term treatment of acute depression in adults.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.