Understanding the molecular mechanisms underlying Alzheimer's disease

The accumulation of amyloid-β (Aβ) in the brains of Alzheimer's disease (AD) patients is known to be associated with memory loss and neuronal degeneration, but the mechanism of Aβ pathogenesis is not fully understood.

In this issue of the Journal of Clinical Investigation, researchers led by Yong-Keun Jung at Seoul National University demonstrate that Aβ binds to a known as FCγRIIb.

Greater levels of FCγRIIb were detected in the brains of AD patients. Binding of Aβ to FCγRIIb activated cell stress and death pathways. In a mouse model of AD, depletion of FCγRIIb ameliorated memory impairment.

This study demonstrates that FCγRIIb plays a critical role in AD pathogenesis.


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More information: FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease, J Clin Invest. doi:10.1172/JCI66827
Citation: Understanding the molecular mechanisms underlying Alzheimer's disease (2013, June 10) retrieved 16 July 2019 from https://medicalxpress.com/news/2013-06-molecular-mechanisms-underlying-alzheimer-disease.html
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