Fruit fly studies shed light on adaptability of nerve cells
Changes in the functional connections between neurons - 'synapses' - contribute to our ability to adapt to environmental changes. However until now, little was known about the signalling underlying such 'synaptic plasticity'. Now, investigations of fruit flies by researchers at the German Center for Neurodegenerative Diseases (DZNE), Tokyo Tech, the National Institute of Genetics in Japan, and the European Neuroscience Institute in Germany reveal details of the mechanisms behind synaptic plasticity.
"The synaptic changes that we have identified might reflect an innate neuronal property that leads to protection from excessive stimuli," explains Dr. Atsushi Sugie, the study's lead author and Postdoc at DZNE. "By enhancing this property, we might be able to protect neurons from degeneration or cell death."
Recent studies have suggested that changes in a region at the presynaptic membrane, described as the active zone, control synapse function. The research teams based in Germany and Japan exposed living fruit flies - the commonly studied Drosophila - to different light regimes and then compared the active zones in the photoreceptors.
T-shaped structures at the presynaptic membrane tether synaptic vesicles and control the release of neurotransmitters to the postsynaptic neuron. By tagging proteins that are crucial to these T-shaped structures the researchers revealed a drop in a subset of active zone proteins, while others remained unchanged. Further, they found that corresponding to the loss of structural proteins, the number of T-shaped structures was also reduced.
The researchers were also able to identify that a feedback mechanism was responsible for these changes and that it relied on the signalling protein Wnt. The results contribute to a better understanding of the molecular mechanisms underlying brain functions such as learning and memory. Future work may investigate how modifying the Wnt signal can be used to manipulate synaptic plasticity, with possible therapeutic applications for neurodegenerative or mental diseases.