Study solves mystery of memory and mood

Research solves mystery of memory and mood
Dr. Dhanisha Jhaveri of the Queensland Brain Institute at The University of Queensland. Credit: The University of Queensland

Scientists are one step closer to understanding how the brain regulates memory and mood, thanks to the discovery of two distinct types of stem cells.

University of Queensland researchers have identified two types of in the hippocampus, a region of the brain crucial for and memory.

Dr Dhanisha Jhaveri, the study's lead author, said Queensland Brain Institute (QBI) researchers had isolated pure populations of these cells for the first time.

The discovery may have implications for the treatment of learning- and mood-related disorders.

"The stem cells we have identified give rise to new ," Dr Jhaveri said.

"The production of new neurons in the brain, a process that decreases as we age, is essential for learning and cognitive function."

Professor Perry Bartlett, QBI director, said the discovery solved a about the birth of new neurons in the hippocampus.

"Previously, these neurons were all thought to be identical, so it wasn't understood how the region is able to regulate behaviours as divergent as learning and mood," he said.

"The existence of distinct stem cell populations suggests that they give rise to different types of neurons, which explains the varied functions of the hippocampus."

Dr Jhaveri said the discovery was made using state-of-the-art cell-sorting and DNA technologies.

"The two cell groups are located in different regions of the hippocampus, which suggests that distinct areas within the control spatial learning versus mood," she said.

"When we purified the cells we found that they are activated by different mechanisms, and generate new neurons that differ in their gene expression."

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More information: The study, Purification of neural precursor cells reveals the presence of distinct, stimulus-specific subpopulations of quiescent precursors in the adult mouse hippocampus, is published in The Journal of Neuroscience.
Journal information: Journal of Neuroscience

Citation: Study solves mystery of memory and mood (2015, June 1) retrieved 23 July 2019 from
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Jun 01, 2015
http://www.ncbi.n...3960065/ Excerpt: "The honeybee already serves as a model organism for studying human immunity, disease resistance, allergic reaction, circadian rhythms, antibiotic resistance, the development of the brain and behavior, mental health, longevity, diseases of the X chromosome, learning and memory, as well as conditioned responses to sensory stimuli (Kohl, 2012)."

If you cannot understand virus-driven RNA-mediated cell type differentiation via amino acid substitutions, you will never understand how cell type differentiation occurs during life history transitions of any species.

See also: Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults http://link.sprin...4-0895-5

Jun 01, 2015
Conclusion from: http://www.jneuro...abstract

"Ultimately, understanding the functional contribution of new neurons generated by activating these distinct subpopulations will be essential to guide future regenerative strategies for the treatment of learning- and mood-related disorders."

They cite McEwen BS (1999) Stress and hippocampal plasticity. Annu Rev Neurosci 22:105–122.

Unfortunately, they do not seem to understand the difference between an epigenetic effect of stress on hormone-organized and hormone-activated RNA-mediated cell type differentiation in the brain and the affect of hormones on behavior that is clearly linked to cell type differentiation during development.

See also: Correction for McEwen, Brain on stress: How the social environment gets under the skin http://www.pnas.o....2.short

..."effect" should instead appear as "affect."

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