New clues found to vision loss in macular degeneration?

New clues found to vision loss in macular degeneration?
In this image of the retina, normal blood vessels (green) surround a clump of new, abnormal vessels that has formed beneath the center of the retina. Scientists at Washington University School of Medicine in St. Louis have identified a molecular pathway that leads to the formation of such blood vessels, which can cause blindness in people with age-related macular degeneration. Credit: Washington University School of Medicine

Scientists have identified a pathway that leads to the formation of atypical blood vessels that can cause blindness in people with age-related macular degeneration.

The research, at Washington University School of Medicine in St. Louis, sheds light on one of the leading causes of blindness in industrialized countries and offers potential targets for treating the disease.

The study is published online Aug. 11 in the journal Nature Communications.

"Our research increases our understanding of how specific can contribute to vision loss in macular degeneration, and it also may help us identify treatments by giving us a molecular pathway to target," said principal investigator and retina specialist Rajendra S. Apte, MD, PhD. "When we inhibit this pathway, we can alter the immune cells and interfere with abnormal blood in mice. Doing so might open therapeutic avenues to halt vision loss or even restore sight in people who have macular degeneration, the leading cause of blindness in people over 50."

Apte, the Paul Cibis Distinguished Professor of Ophthalmology and Visual Sciences at the School of Medicine, has spent years studying the immune system in the eye to distinguish changes related to aging from those related to disease. In earlier work, he found that a cell-signaling molecule, called interleukin-10 (IL10), plays a role in the formation of involved in the "wet" form of macular degeneration, which is more frequently linked to blindness than the "dry" form of the disease.

Before vision loss occurs, IL10 levels increase in the eye, as do the number of specific immune cells, called M2 macrophages. These macrophages are known to contribute to the development of damaging blood vessel growth beneath the retina.

Credit: Washington University BioMed Radio

Until now, though, how IL10 actually contributed to the proliferation of macrophages and damaging blood vessels wasn't well understood. So Apte and his colleagues engineered mice in which various cell-signaling pathways were disabled. Those experiments led them to discover that a specific signaling pathway involving a protein called STAT3 was activating and altering immune cells in the eye, and those cells then spurred the formation of harmful blood vessels.

Further, they examined eye tissue from patients treated in the 1980s and 1990s, when surgery to remove from underneath the retina was routinely performed on patients with the wet form of macular degeneration. There, too, the same STAT3 protein that was abundant and active in M2 macrophages in mice also was found in high levels in the human tissue.

The findings suggest that the causes of damaging blood vessel growth in people are the same as what the researchers had observed in mouse models, Apte said. In both mice and in patients, abnormal blood vessel growth was linked to macrophages with high levels of the active form of STAT3.

That a cause of significant appears to be the same in mice and people is good news, Apte explained, because some compounds can disrupt the actions of STAT3 in mice and keep the pathway from spurring . Those same compounds may alter the course of in people with the condition.

"Now that we have a better idea of how these are activated at the molecular level, we may be able to use those drugs to halt or reverse the disease process," Apte said.

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More information: Nakamura R, Sene A, Santeford A, Gdoura A, Kubota S, Azpata N, Apte RS. IL10 driven STAT3 signaling in senescent macrophages promotes pathological eye angiogenesis. Nature Communications, published online August 11, 2015. 
Journal information: Nature Communications

Citation: New clues found to vision loss in macular degeneration? (2015, August 11) retrieved 6 July 2020 from
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