Index stratifies risk for advanced colorectal neoplasia

Index stratifies risk for advanced colorectal neoplasia

(HealthDay)—A scoring system can stratify risk for advanced colorectal neoplasia in asymptomatic adults, according to a study published online Aug. 11 in the Annals of Internal Medicine.

Thomas F. Imperiale, M.D., from the Indiana University School of Medicine in Indianapolis, and colleagues conducted a cross-sectional study to create a risk index for advanced neoplasia anywhere in the colorectum, using the most common risk factors for . Data were included for persons aged 50 to 80 years undergoing initial screening colonoscopy.

The researchers found that the prevalence of advanced neoplasia was 9.4 percent among 2,993 persons in the derivation set. For people classified as being at very low, low, intermediate, and high risk, the risks for advanced neoplasia were 1.92, 4.88, 9.93, and 24.9 percent, respectively (P < 0.001). In the low-risk groups, sigmoidoscopy to the descending colon would have detected 73 percent of advanced neoplasms. The corresponding risks for advanced neoplasia were 1.65, 3.31, 10.9, and 22.3 percent, respectively, among the 1,467 persons in the validation set (P < 0.001). Sigmoidoscopy would have detected 87.5 percent of advanced neoplasms.

"The score may be useful in counseling average-risk patients about their risk for ," writes the author of an accompanying editorial. "But until stronger scientific evidence is available, I would not recommend such scores for choosing the type of screening test an average-risk person should have."

Explore further

Factors ID'd for CRC risk stratification with positive FIT

More information: Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Journal information: Annals of Internal Medicine

Copyright © 2015 HealthDay. All rights reserved.

Citation: Index stratifies risk for advanced colorectal neoplasia (2015, August 12) retrieved 17 October 2019 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more