CYP2C19 polymorphisms impacts citalopram metabolism

<i>CYP2C19</i> polymorphisms impacts citalopram metabolism

(HealthDay)—For patients with major depressive disorder, certain CYP2C19 polymorphisms contribute to citalopram (CIT) metabolism, according to research published in the December issue of the Journal of Clinical Pharmacy and Therapeutics.

Z. Uckun, Ph.D., from Mersin University in Turkey, and colleagues determined CYP2C19 genetic polymorphisms and their impact on the metabolism of CIT. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism method in 209 healthy individuals and 50 patients with .

The researchers found that the CYP2C19*1 and CYP2C19*17 allele frequencies were 71.0 and 18.0 percent, respectively, for the healthy group and 81.1 and 18.9 percent, respectively, for the patient group (P > 0.05). Patients with the CYP2C19*1/*1 had significantly higher mean plasma concentration and the mean dose-corrected levels of demethylcitalopram (DCIT) compared to with CYP2C19*1/*2 or CYP2C19*2/*2 genotypes (P < 0.05). In the CYP2C19*1/*2 and CYP2C19*2/*2 genotypes, the mean metabolic ratio (MR, CIT/DCIT) was significantly higher (P < 0.05). Plasma CIT, DCIT concentrations, and MR value did not differ for the CYP2C19*1/*1 and CYP2C19*1/*17 genotypes (P > 0.05).

"Our data suggest that CYP2C19*17 polymorphism does not have a significant effect on CIT metabolism," the authors write. "In contrast CYP2C19*2 polymorphism has a prominent role and is likely to contribute to interindividual variability in CIT metabolism in vivo at therapeutic doses."

More information: Abstract
Full Text (subscription or payment may be required)

Copyright © 2015 HealthDay. All rights reserved.

Citation: CYP2C19 polymorphisms impacts citalopram metabolism (2015, December 14) retrieved 18 March 2024 from https://medicalxpress.com/news/2015-12-cyp2c19-polymorphisms-impacts-citalopram-metabolism.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

CYP2C19 polymorphism impacts response to PPI Tx in GERD

0 shares

Feedback to editors