Findings do not support use of vitamin D to reduce pain from knee osteoarthritis

March 8, 2016, The JAMA Network Journals

Vitamin D supplementation for individuals with knee osteoarthritis and low 25-hydroxyvitamin D levels did not reduce knee pain or slow cartilage loss, according to a study appearing in the March 8 issue of JAMA.

Symptomatic occurs among 10 percent of men and 13 percent of women age 60 years or older. Currently there are no disease-modifying therapies for osteoarthritis. Vitamin D can reduce bone turnover and degradation, thus potentially preventing the development and progression of knee osteoarthritis. Observational studies suggest that vitamin D supplementation is associated with benefits for knee osteoarthritis, but current evidence from clinical trials is contradictory.

Changhai Ding, M.D., Ph.D., of the University of Tasmania, Hobart, Tasmania, Australia, and colleagues randomly assigned 413 patients with symptomatic knee osteoarthritis and low 25-hydroxyvitamin D to receive monthly treatment with oral vitamin D3 (50,000 IU; n = 209) or an identical placebo (n = 204) for 2 years. The study was conducted in Tasmania and Melbourne, Australia.

Of 413 enrolled participants (average age, 63 years; 50 percent women), 340 (82 percent) completed the study. The researchers found that vitamin D supplementation, compared with placebo, did not result in significant differences in change in MRI-measured tibial cartilage volume or a measure of over 2 years. There were also no significant differences in change of tibiofemoral cartilage defects or change in tibiofemoral bone marrow lesions. Vitamin D levels did increase more in the vitamin D group than in the placebo group over 2 years.

"These data suggest a lack of evidence to support D supplementation for slowing disease progression or structural change in knee osteoarthritis," the authors write.

Explore further: Vitamin D supplementation does not reduce knee pain, cartilage loss in patients with osteoarthritis

More information: JAMA, DOI: 10.1001/jama.2016.1961

Related Stories

Vitamin D supplementation does not reduce knee pain, cartilage loss in patients with osteoarthritis

January 8, 2013
In a two year randomized trial, patients with symptomatic knee osteoarthritis who received vitamin D supplementation did not have a significant difference in knee pain or cartilage volume loss compared to patients who received ...

Low vitamin D linked to osteoarthritis in the knee

July 15, 2015
As you get older, chances are you may have noticed your knees are less forgiving when it comes to jaunting up and down the stairs. Now, a study supported in part by USDA-funded researchers suggests if you're not getting adequate ...

MRI reveals weight loss protects knees

November 30, 2015
Obese people who lose a substantial amount of weight can significantly slow the degeneration of their knee cartilage, according to a new MRI study presented today at the annual meeting of the Radiological Society of North ...

Knee bracing no benefit over nonoperative program in knee OA

November 17, 2015
(HealthDay)—For patients with knee osteoarthritis (OA), knee bracing offers no benefit over a multidisciplinary nonoperative program, according to a study published online Nov. 12 in the International Journal of Rheumatic ...

Vitamin study outlines risks for joints, but not everyone should take supplements, nutrition researcher says

September 18, 2015
People who are lacking in vitamin D could be doubling their risk for progressive osteoarthritis, the cartilage-eroding joint disease that with age leads to achy knees and mobility problems.

Medial, not lateral, femorotibial cartilage change predictive of OA

December 14, 2015
(HealthDay)—For patients with knee osteoarthritis (OA), cartilage thickness change is associated with radiographic and pain progression, according to a study published in the December issue of Arthritis & Rheumatology.

Recommended for you

Joint resolution: A link between Huntington's disease and rheumatoid arthritis

May 15, 2018
Using new analytic tools, researchers at University of California San Diego School of Medicine and the Icahn School of Medicine at Mount Sinai have decoded the epigenetic landscape for rheumatoid arthritis (RA), a common ...

Get off the golf cart if you have knee osteoarthritis

April 28, 2018
From presidents to retirees, more than 17 million people over the age of 50 golf regularly. Knee osteoarthritis, which causes swelling, pain and difficulty moving the joint, is one of the leading causes of disability in this ...

How environmental pollutants and genetics work together in rheumatoid arthritis

April 19, 2018
It has been known for more than three decades that individuals with a particular version of a gene—human leukocyte antigen (HLA)—have an increased risk for rheumatoid arthritis.

The bugs in your gut could make you weak in the knees

April 19, 2018
Bacteria in the gut, known as the gut microbiome, could be the culprit behind arthritis and joint pain that plagues people who are obese, according to a new study published today in JCI Insight.

Researchers identify peptide produced during cartilage deterioration as a potential source of osteoarthritis pain

April 11, 2018
Osteoarthritis is one of the most common causes of chronic pain in the world. More than 30 million people in the United States alone suffer from osteoarthritis, or OA, which can affect any moveable joint of the body, including ...

Flare-responsive hydrogel developed to treat arthritis

April 3, 2018
Arthritis flares - the unpredictable and often sudden worsening of arthritis symptoms—can be debilitating. These episodes can make the management of inflammatory arthritis, which includes rheumatoid arthritis and psoriatic ...

1 comment

Adjust slider to filter visible comments by rank

Display comments: newest first

drj27
not rated yet Mar 09, 2016
Useless study, 50,000 units once a month? Of course it's negative. Dosing needs to be daily and in adequate amounts 5000 to 10000 units every day!

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.