Iodine-125 interstitial implant feasible for prostate cancer

Iodine-125 interstitial implant feasible for prostate cancer

(HealthDay)—Iodine-125 permanent interstitial implantation is associated with long-term, biochemical control of localized prostate cancer, according to a study published online March 28 in the Journal of Medical Imaging and Radiation Oncology.

Craig Wilson, M.B.B.S., from Sir Charles Gairdner Hospital in Nedlands, Australia, and colleagues treated consecutive 207 patients with localized (September 1994 to November 2007) with iodine-125 permanent interstitial implantation. Three times a month, post-therapy assessment was conducted for clinical review and biochemical (prostate-specific antigen [PSA]) evaluation.

The researchers found that over a median follow-up of 7.8 years the 10-year biochemical disease-free survival (bDFS) for the entire cohort was 89 percent. By pre-treatment risk group, the 10-year bDFS estimates were 96 percent for low-risk, 83 percent for intermediate-risk, and 50 percent for high-risk disease. Pre-treatment PSA was an independent predictor of bDFS in multivariate analysis. There was not a significant effect of D90 dose (maximum dose delivered to 90 percent of the prostate volume) on bDFS. Late grade 3 or higher urinary and rectal toxicities had peak incidences of 10.7 and 1.1 percent, respectively.

"Excellent long-term biochemical control was demonstrated with iodine-125 permanent interstitial implantation in appropriately selected patients with prostate cancer," the authors write.


Explore further

For prostate cancer, more radiation may not improve survival

More information: Abstract
Full Text (subscription or payment may be required)

Copyright © 2016 HealthDay. All rights reserved.

Citation: Iodine-125 interstitial implant feasible for prostate cancer (2016, April 12) retrieved 20 August 2019 from https://medicalxpress.com/news/2016-04-iodine-interstitial-implant-feasible-prostate.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
9 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more