Anaphylaxis risk up for siblings of peanut allergic children

June 14, 2016

(HealthDay)—The risk of anaphylaxis is increased upon peanut introduction in siblings of children with peanut allergy, according to a study published online June 13 in Allergy.

Philippe Bégin, M.D., Ph.D., from Centre Hospitalier Universitaire Sainte-Justine in Montreal, and colleagues conducted double-blinded skin testing in 154 -naive younger siblings of peanut allergic children, followed by parent-led peanut introduction. Parents completed questionnaires to examine preferences with respect to peanut introduction.

The researchers found that there were unequivocal immunoglobulin E (IgE)-mediated reactions to peanut upon introduction in 5.2 percent of participants, including five anaphylaxes. Compared with the rest of the cohort, these participants were significantly older (median, 4.0 versus 1.9 years; P = 0.04). The negative predictive value of skin prick test was 99, 100, and 100 percent with peanut extract, , and specific IgE, respectively. Positive peanut allergy tests were seen for six peanut tolerant participants. Compared with supervised introduction or home introduction after negative skin test, the option of introducing at home without prior test was associated with high levels of anxiety (median 8.4 versus 3.8 and 4.3 on 10-point Likert scale, respectively; both P < 0.0001).

"There is an increased risk of anaphylaxis upon peanut introduction in siblings of children with and parents are reluctant to introduce at home without testing," the authors write.

Explore further: Video: Why are people allergic to peanuts?

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Video: Why are people allergic to peanuts?

March 22, 2016
For 1 to 2 percent of the global population, eating a peanut butter and jelly sandwich could be potentially fatal. What makes peanut allergies so lethal, and why is the number of peanut-allergy sufferers on the rise?

Peanut allergy prevention strategy is nutritionally safe, study shows

June 10, 2016
Introducing peanut-containing foods during infancy as a peanut allergy prevention strategy does not compromise the duration of breastfeeding or affect children's growth and nutritional intakes, new findings show. The work, ...

Gene-environment connection seen in peanut allergy study

December 15, 2014
(HealthDay)—Infants of a particular generation born in Australia to Asian-born parents appeared to have an increased risk of peanut allergy compared with those of Australian-born parents, according to research published ...

Eating peanut in early years helps reduce risk of allergy even with later abstinence

March 4, 2016
The early introduction of peanut to the diets of infants at high-risk of developing peanut allergy significantly reduces the risk of peanut allergy until 6 years of age, even if they stop eating peanut around the age of five, ...

Early introduction of allergenic foods reduces risk of food sensitization

May 18, 2016
Children who had a diet that included cow's milk products, egg and peanut before age one were less likely to develop sensitization to the corresponding foods, according to new research presented at the ATS 2016 International ...

Many children with asthma have reaction to peanuts, but do not know it

May 17, 2015
In recent years and months, peanut allergies in children have been in the news frequently, as scientists reveal new insights into why more and more children are developing them and what can be done to avoid them. However, ...

Recommended for you

A gut bacterium as a fountain of youth? Well, let's start with reversing insulin resistance

November 16, 2018
Move over Bifidobacterium and Lactobacillus. There's a new health-promoting gut bacterium in town, and it's called Akkermansia muciniphila.

New inflammation inhibitor discovered

November 16, 2018
A multidisciplinary team of researchers led from Karolinska Institutet in Sweden have developed an anti-inflammatory drug molecule with a new mechanism of action. By inhibiting a certain protein, the researchers were able ...

Pets can double as asthma antidote

November 16, 2018
(HealthDay)—The "hygiene hypothesis" holds that early exposure to a variety of microorganisms may decrease the risk for chronic inflammatory diseases, like asthma.

New study shows NKT cell subsets play a large role in the advancement of NAFLD

November 16, 2018
Since 2015 it has been known that the gut microbiota could have a direct impact on nonalcoholic fatty liver disease (NAFLD), which affects up to 12% of adults and is a leading cause of chronic liver disease. In the November ...

Defense against intestinal infection in organism is affected by prostaglandin E2

November 15, 2018
The treatment of intestinal infections caused by some strains of the bacterium Escherichia coli, present in unsanitized or contaminated foods, may have a new ally.

No link between 'hypoallergenic' dogs and lower risk of childhood asthma

November 15, 2018
Growing up with dogs is linked to a lower risk of asthma, especially if the dogs are female, a new study from Karolinska Institutet and Uppsala University in Sweden shows. However, the researchers found no relation between ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.