Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells

June 29, 2016
Preliminary lab studies by Salk Professor David Schubert suggest that the molecule THC reduces beta amyloid proteins in human neurons. Credit: Salk Institute

Salk Institute scientists have found preliminary evidence that tetrahydrocannabinol (THC) and other compounds found in marijuana can promote the cellular removal of amyloid beta, a toxic protein associated with Alzheimer's disease.

While these exploratory studies were conducted in neurons grown in the laboratory, they may offer insight into the role of inflammation in Alzheimer's disease and could provide clues to developing novel therapeutics for the disorder.

"Although other studies have offered evidence that cannabinoids might be neuroprotective against the symptoms of Alzheimer's, we believe our study is the first to demonstrate that cannabinoids affect both inflammation and amyloid beta accumulation in nerve cells," says Salk Professor David Schubert, the senior author of the paper.

Alzheimer's disease is a progressive brain disorder that leads to memory loss and can seriously impair a person's ability to carry out daily tasks. It affects more than five million Americans according to the National Institutes of Health, and is a leading cause of death. It is also the most common cause of dementia and its incidence is expected to triple during the next 50 years.

It has long been known that amyloid beta accumulates within the nerve cells of the aging brain well before the appearance of Alzheimer's disease symptoms and plaques. Amyloid beta is a major component of the plaque deposits that are a hallmark of the disease. But the precise role of amyloid beta and the plaques it forms in the disease process remains unclear.

In a manuscript published in June 2016's Aging and Mechanisms of Disease, Salk team studied nerve cells altered to produce high levels of amyloid beta to mimic aspects of Alzheimer's disease.

The researchers found that high levels of amyloid beta were associated with cellular inflammation and higher rates of neuron death. They demonstrated that exposing the cells to THC reduced amyloid beta protein levels and eliminated the from the nerve cells caused by the protein, thereby allowing the nerve cells to survive.

"Inflammation within the brain is a major component of the damage associated with Alzheimer's disease, but it has always been assumed that this response was coming from immune-like cells in the brain, not the nerve cells themselves," says Antonio Currais, a postdoctoral researcher in Schubert's laboratory and first author of the paper. "When we were able to identify the molecular basis of the inflammatory response to amyloid beta, it became clear that THC-like compounds that the nerve cells make themselves may be involved in protecting the cells from dying."

Brain cells have switches known as receptors that can be activated by endocannabinoids, a class of lipid molecules made by the body that are used for intercellular signaling in the brain. The psychoactive effects of marijuana are caused by THC, a molecule similar in activity to endocannabinoids that can activate the same receptors. Physical activity results in the production of endocannabinoids and some studies have shown that exercise may slow the progression of Alzheimer's disease.

Schubert emphasized that his team's findings were conducted in exploratory laboratory models, and that the use of THC-like compounds as a therapy would need to be tested in clinical trials.

In separate but related research, his lab found an Alzheimer's drug candidate called J147 that also removes amyloid beta from nerve cells and reduces the inflammatory response in both and the brain. It was the study of J147 that led the scientists to discover that endocannabinoids are involved in the removal of amyloid beta and the reduction of inflammation.

Explore further: Blocking inflammation prevents cell death, improves memory in Alzheimer's disease

More information: Antonio Currais et al. Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids, npj Aging and Mechanisms of Disease (2016). DOI: 10.1038/npjamd.2016.12

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69 comments

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cantdrive85
2.8 / 5 (16) Jun 29, 2016
Needless to say, I should not ever suffer from such an affliction.
Shootist
2.5 / 5 (16) Jun 29, 2016
Free the weed
BONK__RS
4 / 5 (4) Jun 29, 2016
...and could provide clues to developing novel therapeutics for the disorder.
And possibly some not-so-novel therapeutics?
exmauler
2.7 / 5 (7) Jun 29, 2016
Well imagine that. Of course this is just another study to be repressed.
pporpoiseboy
3.7 / 5 (3) Jun 29, 2016
WHEW! i will give up a little short term memory loss ( while high ) to not get that bastard of a disease. almost a daily user of cannabis here and happier than ever about that.
Otto_Szucks
1.4 / 5 (10) Jun 29, 2016
Tommy Chong has prostate cancer. But he's till got all his marbles.
gkam
1.4 / 5 (9) Jun 29, 2016
Chocolate, coffee and cannabis good for us: How lucky can we get?
retrosurf
5 / 5 (1) Jun 30, 2016
Is that a Leitz IRB fractionating infrared vaporizer that I see there, all warmed up and ready to go?
Captain Stumpy
2.6 / 5 (10) Jun 30, 2016
cannabis good for us: How lucky can we get?
not if you're driving

like i told you before:
http://epirev.oxf...65.short

http://aje.oxford...92.short

http://www.scienc...13003527

http://onlinelibr...Message=

Lex Talonis
1 / 5 (4) Jun 30, 2016
Awesome - you can be paranoid about brain rot.
unrealone1
2.3 / 5 (3) Jun 30, 2016
I guess all the conspiracy theories where right. Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells.
gkam
1.4 / 5 (9) Jun 30, 2016
The tests I saw, done by police, showed the normal cannabis users doing better in driving tests on weed than off of it.
gkam
1 / 5 (7) Jun 30, 2016
removed by me
Captain Stumpy
3 / 5 (10) Jun 30, 2016
The tests I saw, done by police, showed the normal cannabis users doing better in driving tests on weed than off of it.
1- calling BULLSH*T

2- you are definitely lying about that one because the linked studies above demonstrate that being DUI with weed is not only increasing but is also cause in increased fatalities (you can also see that in news out of WA state)

3- Cannabis affects motor function, ya idiot
http://www.ncbi.n...3037578/

Experimental studies have repeatedly shown that THC impairs cognition, psychomotor function and actual driving performance ...
http://www.drugan...abstract

http://www.nature...68a.html

just because you're a burnt dementia patient wanting to toke up doesn't mean you know anything about cannabis

and this proves it: you absolutely LIED about the test you saw & police etc
gkam
1.9 / 5 (9) Jun 30, 2016
"you are definitely lying "
---------------------------

No, Toots, I am not.

Is your hate so extreme that you look for any excuse to abuse me? I know I pissed you off with something, probably your falling for "WMD!" and the Bush Wars of Mass Profit, but you have to outgrow it.
Uncle Ira
4 / 5 (12) Jun 30, 2016
The tests I saw, done by police, showed the normal cannabis users doing better in driving tests on weed than off of it.
1- calling BULLSH*T
Ira-Skippy has already tried that. He told me that one too. You would think that the police giving peoples a taste of illegal substances would be news worthy, eh? Non, it is so ho-hum that not even a local reporter covered him.

Thing about making up news stories out of the thin air (or thick smoke, eh?) the more outlandish they are, the more someone might try to find out a little more about it. The only thing we could find (there was two of working full-time on that one, VietVet-Skippy and me) was that glam-Skippy was the only person in the world that knew about it.
Captain Stumpy
2.6 / 5 (10) Jun 30, 2016
No, Toots, I am not
@liar-kam
oh, then you can provide a link or reference to validate the claim then?
no?

i offered you 7 studies above that demonstrate, with evidence, that you're wrong about that topic
if you don't believe the VALIDATED studies, you can always read them yourself
https://scholar.g...as_sdtp=

there are about 18,900 results in that search alone (limited to only "cannibis affects motor function")
but feel free to offer your "experience" and all that medical training and know-how to prove your comment about being a better driver on cannabis

maybe pachinko can help you with that one
i hesitate to see what he'll say about these studies... maybe the scope is all wrong?
or all that wording is too vague to prove my point?

ask her!

but link your evidence/reference first!
thanks!
FOAD
gkam
1 / 5 (8) Jun 30, 2016
Yeah, and I will send it after you send me the DD-214 you said you would send.

Then, we can compare performance reports.
TheGhostofOtto1923
2.4 / 5 (14) Jun 30, 2016
Uh oh george kamburoff the lying cheating psychopath, who lies about his service record for shits and giggles, is on a manic posting surge @1 post every 5 mins or so.

You get this way every year around the 4th georgie?

I would guess its guilt for lies about your service record but psychopaths just dont feel those sorts of things do they? So it must be a medication issue.

You know, the stuff you get from the VA for that pesky 40yr case of 'PTD' you told us about? Or blood cancer or some other case of situational hypochondria -?

"Manipulation is the key to the psychopath's conquests. Initially, the psychopath will feign false emotions to create empathy, and many of them study the tricks that can be employed by the empathy technique. Psychopaths are often able to incite pity from people because they seem like "lost souls" as Guggenbuhl-Craig writes. So the pity factor is one reason why victims often fall for these "poor" people."

POOR poor georgie.
geoh777
3 / 5 (2) Jun 30, 2016
My toothpaste takes care of my plaque problems, so not applicable. And I'm short on protein anyway.
yep
2.2 / 5 (13) Jul 01, 2016
cannabis good for us: How lucky can we get?
not if you're driving
like i told you before:

Well let's see what the latest studies say?
http://thefreetho...rijuana/
Last time I was in Holland having a morning smoke at the coffe shop I entered into a conversation with Dutch postman who said that since all their studies had shown cannabis was not correlated to accidents he end every other Dutch person except police persons were allowed to enjoy cannabis, and it's not so much that the Dutch love Cannabis it's more so that the Dutch love Freedom!
So why don't you really do some digging and learn about our "free" market starting with Popular Mechanics February 1938 article titled " The Billion Dollar Crop "

I think if you educate yourself you might understand why a propaganda campaign has been foisted on the American public for 70 + years.
yep
2.1 / 5 (11) Jul 01, 2016
This campaign contrary to every state and federal study since the Army's Panama Canal Zone Marijuana 1916-1933, Laguardia 1944, Shafer, 1973, California 1999.

Ignoring history and science makes for pawns and dupes.
cantdrive85
1.8 / 5 (10) Jul 01, 2016
One of my favorite activities was smoking a few phat bong rips and then blazing around the mountain roads outside Denver on my Ducati S4R. Pure unadulterated pleasure, focus, and excitement.

Unfortunately had to give it up due to drunk drivers and stupid ass old people and their shitty driving. Following two hit and run accidents, one DD and one old ass POS (probably Cap'n Stoopid), I have had to give up my dear hobby. Now stuck to bong rips and riding the couch....
Captain Stumpy
2.8 / 5 (9) Jul 02, 2016
Well let's see what the latest studies say?
@yep
1- that was a blog, not a study
2- it isn't validated, whereas the links i provided were to validated studies
3- it's not that i am against MJ. i am not. i do not, however, advocate for driving or operating under the influence of any psychotropic, motor function inhibitor, CNS depressant or anything that is proven to affect the majority of the population

this isn't about outliers either: i know that certain factors play a large role
weight, body mass, metabolism, tolerances, etc

however, the bulk of the population fall under the studies i posted above
it is proven, not only in science, but by looking at the spike in fatalities in state accidents: DUI with MJ

as noted in this article: http://seattle.cb...tripled/

Captain Stumpy
2.8 / 5 (9) Jul 02, 2016
@yep cont'd
I think if you educate yourself
1- i am the one producing the validated studies

2- repeating a lie b/c you want it to be true doesn't make it true or reality
you do this with eu as well

.

One of my favorite activities was smoking a few phat bong rips and then blazing around the mountain roads
@cd
imagine that: you're burnt
it's really too bad you didn't have a fatality
it would have done the world a lot of good
Unfortunately had to give it up
i suggest you try sky-diving while burnt
maybe even sans chute
probably Cap'n
i've never once driven impaired
you can't seem to even type or post without being impaired, however
and now you can't even blame it on the weed
no wonder you're a conspiracy junkie
Captain Stumpy
2.8 / 5 (9) Jul 02, 2016
Well let's see what the latest studies say?
http://thefreetho...rijuana/

maybe you also missed this part in the study?
SDLP was a sensitive cannabis-related lateral control impairment measure. During drive blood THC ≥8.2 μg/L increased SDLP similar to notably-impairing alcohol concentrations
that doesn't say it is safe to drive with cannabis, nor does it say absolutely "No Driving Impairment".
nor does it mean it's safe to drive under the influence

.

So why don't you really do some digging and learn
I think if you educate yourself you might understand something other than your delusional beliefs
Ignoring history and science makes for pawns and dupes
gkam
1.8 / 5 (10) Jul 02, 2016
"it's really too bad you didn't have a fatality"
---------------------------------

Please re-read that post.
cantdrive85
2.3 / 5 (6) Jul 02, 2016
"it's really too bad you didn't have a fatality"

I have to assume that comment is from Cap'n Stoopid, goes to show his character or lack thereof. Not at all surprising coming from a nearly dead bitter old POS.
yep
2.6 / 5 (5) Jul 02, 2016
yep
2.6 / 5 (5) Jul 02, 2016
Ok Capt. read this very slowly to understand,
http://bigstory.a...-driving
I remmeber the first study I read around the mid to late eighties the measurable impairment of canabis users to sober drivers was in the tenths to hundreths compared to the single to double digits for alcohol.
You ought to be more worried about those pharmaceutical drugs dispensed like candy.

yep
2.6 / 5 (5) Jul 02, 2016
"Driving with a noisy child in the back is as dangerous as driving on marijuana"

gkam
2 / 5 (8) Jul 02, 2016
More so, yep.
yankee2
2.1 / 5 (7) Jul 03, 2016
I think it's very funny that after decades of dishonest propaganda regarding marijuana, including about its health effects, it may very well turn out that we are the healthiest cohort on the planet! If this is true (and there is every likelihood it is), and if Donald Tashkin's findings regarding "The effect of smoked marijuana on the lungs" also stand up, it seems that lifelong potheads will suffer less cancer and fewer cases of Altzheimer's disease, two of the most serious afflictions people suffer as we age, than the general population. LOL!!! I guess the joke's on the prohibitionists, and those who believed their lies...
yankee2
2.5 / 5 (8) Jul 03, 2016
That the American public has been denied the beneficial health efffects of cannabis all these decades... add that to the long list of injustices inflicted on the American People, by a government which clearly serves either racism and bigotry, or else a rich plutocracy, or both, but CERTAINLY not the American people ourselves! Imagine how many lives could have been saved over the last 50 years, if Americans had been encouraged to use marijuana instead of alcohol! Marijuana not only reduces traffic accidents, it may very well reduce the incidence of several major medical killers, including lung cancer and Altzheimer's disease. There is very little evidence (like NONE) that cannabis CAUSES any disease, apart from minor, non-progressive bronchitis. To a very large degree, the effects of cannabis on society seem to be POSITIVE.
yankee2
3 / 5 (8) Jul 03, 2016
Captain Stumpy, YES if you're driving. There is no evidence that moderate cannabis use impairs driving at the level of safety. The effects of cannabis on driving are distinctly different from those of alcohol. Whereas alcohol increases aggression and reduces inhibition, leading to more and more severe accidents, marijuana reduces aggression and increases inhibition, leading to fewer and less severe accidents. Another way to put it is to say that drivers under the influence of alcohol fail to recognize their relatively severe impairment AND fail to compensate for it, leading to more accidents, whereas drivers under the influence of cannabis DO recognize their relatively minor impairment and actively compensate for it, e.g. by deliberately focusing on their driving and by slowing down, leading to fewer accidents. I myself have been driving stoned almost every day of my life, yet my driving record is vastly superior to that of my tea-totaling, PhD wife. This is NOT a coincidence!
Captain Stumpy
2.8 / 5 (9) Jul 03, 2016
Ok Capt. read this very slowly to understand
@yep
i'll type this slowly so you can read it cause i know you're illiterate

try re-reading the CONCLUSIONS i posted from your own study again
During drive blood THC ≥8.2 μg/L increased SDLP similar to notably-impairing alcohol concentrations.
wow... kinda f*cking means it's similar, as in, impaired!

also note: driving slower because you're impaired doesn't mean you're not as likely to cause an accident -it's still an offense and regardless of your repeating the study link in a different site it also means it still affects motor control, you idiot

perhaps i should have typed that slower the first time so you didn't get confused, since i know you're illiterate?

.

.

There is no evidence ... impairs driving at the level of safety
@yankee2
1- the first 7 scientific validated studies i linked say differently
2- i'm not anti-MJ.
i AM anti DUI.

read the studies i linked
Captain Stumpy
2.8 / 5 (9) Jul 03, 2016
@yankee cont'd
marijuana reduces aggression and increases inhibition, leading to fewer and less severe accidents.
again: driving slower doesn't mean safer
killing or hurting someone at 25mph is still DUI. it doesn't matter that you're going slow

i agree that DUI-alcohol is a far worse thing. not arguing that point
it's legal and easily available

HOWEVER
as i noted above, the science (validated, not just singular like yep's link) proves that "THC impairs cognition, psychomotor function and actual driving performance"

that is quoted right out of my studies, BTW. it's not "propaganda". it's validated
see Google Scholar if you don't believe me

and the numbers of fatalities from the nation are also supporting my claim

feel free to pull those stats up if you want
they're mentioned in the article i linked above (the article, not the studies)
Captain Stumpy
2.8 / 5 (9) Jul 03, 2016
@yankee2 cont'd
I myself have been driving stoned almost every day of my life, yet my driving record is vastly superior to that of my tea-totaling, PhD wife
everyone's skills at driving are different
this may be due to far more factors than MJ

again, i am not anti MJ or THC
it's been proven effective in a lot of areas

i just don't agree that it's safe to drive on, regardless of your anecdotal evidence. you are a singular person and may well be an outlier in the statistics

MJ affects everyone differently, and there are a *lot* of factors involved in how it affects someone, from body mass to meals and additional imbibing (as noted in yep's study)

i am all for MJ over alcohol. it's never been a prob for me. i've lived in places it's legal

I am totally against DUI driving of any kind, however, and i proved my point RE: MJ above

.

.

.

"Driving with a noisy child...
@Yep
sorry for the downrate; page jumped
you deserved a 5 star
my bad - sorry
stripeless_zebra
5 / 5 (2) Jul 03, 2016
The worst side effect of removing amyloids beta is a lengthy jail time.
TheGhostofOtto1923
3.5 / 5 (8) Jul 03, 2016
marijuana reduces aggression and increases inhibition, leading to fewer and less severe accidents
Pot increases confusion and paranoia leading to more accidents and idiot drivers doing unexpected and irrational things, leading to more accidents.

Did I repeat myself? Stoners do that a lot.
gkam
1 / 5 (6) Jul 03, 2016
Yankee, Rumpy has emotional and ego problems. I just got a nasty email from him full of hate and spewing venom. Normal people do not act like that.

I suggest he put me on "Ignore" so none of us have to see those posts of his attacks.

TheGhostofOtto1923
3.9 / 5 (7) Jul 03, 2016
You sitting on my profile page just waiting for me to show up this morning georgie? How sweet.

Psychopaths crave attention, negative or otherwise. Whatsamatter, can't get a rise out of real people anymore? That's only because as psychopaths go, you're not a very talented one.

As you've amply demonstrated here.
gkam
1 / 5 (5) Jul 03, 2016
Somebody calling it "pot"? That is a someone with no knowledge of it.

It is cannabis, and if you had any experience with it, you would not call it "pot", the sign of a goober who has no experience of his own but blabbers as if he did.
Whydening Gyre
4.5 / 5 (8) Jul 03, 2016
"Driving with a noisy child in the back is as dangerous as driving on marijuana"


and driving with a smartphone in your hand is even worse...
Captain Stumpy
4.3 / 5 (6) Jul 03, 2016
has emotional and ego problems
@stolen valor liar-kam
1- transference - repeating a lie doesn't make it more true

2- you and Nou both apparently aren't able to read the studies

3- thanks for continuing to produce evidence for my favour for when you take me to court... or go after Otto as you promised elswewhere
He will be able to use it in his favour

4- as i stated:
I am not against pot as a study or rec. drug, only as it affects driving and DUI
but don't let all that evidence stop you from downrating like Nou... literacy is a bitch, eh?
Somebody calling it "pot"? That is a someone with no knowledge of it
are you f*cking stupid? learn to GOOGLE
it aint hard and it will keep you from looking like a complete moron
Cannabis is also known as Ganja, grass, Hashish, Hemp, Indian hemp, marijuana, Pot, reefer, weed
https://www.drugs...bis.html
yahroon
2.6 / 5 (5) Jul 03, 2016
It sounds like cannabis can be good for your brain. It can even help you out of a depression.

It surely is proven BAD for your brain if you have a sensitivity in the schizofrenic disorder.
It can even cause psychosis
It for sure enhances paranoid thoughts and can induce psychotic thoughts and behaviour
Just visit a psychiatric center and ask about their thousands of examples in real life.
It is like a mega practical experimentation center.
It also is proven bad for you short term memory, so perhaps it is all about dose.

I am not against cannabis, but it can have severe drawbacks and one should be cautious using it and avoid it in anyway in the above mentioned situations.

For the ones using it and not encountering any problems. Keep enjoying it.
TheGhostofOtto1923
3.9 / 5 (7) Jul 03, 2016
It is cannabis, and if you had any experience with it, you would not call it "pot", the sign of a goober who has no experience of his own but blabbers as if he did
It's funny when imbeciles pretend to be intelligent.
yep
4.2 / 5 (5) Jul 03, 2016
I understand and agree on your point Capt. If you have enough of anything it can impair you just like anger, depression, water, etc.
the fact remains cannabis like caffine used responsibly is not a big "f*cking" deal.
Whydening Gyre
4.5 / 5 (8) Jul 03, 2016
Somebody calling it "pot"? That is a someone with no knowledge of it.
It is cannabis, and if you had any experience with it, you would not call it "pot"...

Think ya got that switched around...
(the sign of someone who has no experience of his own but blabbers as if he did...)
gkam
1 / 5 (10) Jul 03, 2016
None of my sources stores, dispensaries, fellow users, or cops call it "pot". Nobody does unless he thinks it is a big thing. I stopped thinking that in the late 1960's.

Go to Weedmaps and look at the delivery services in the East Bay of Northern CA.

Show me one which uses "pot". They will laugh you off the phone.
Whydening Gyre
4.5 / 5 (8) Jul 03, 2016
I understand and agree on your point Capt. If you have enough of anything it can impair you just like anger, depression, water, etc.
the fact remains cannabis like caffeine used responsibly is not a big "f*cking" deal.

Yep...
Whydening Gyre
4.5 / 5 (8) Jul 03, 2016
None of my sources stores, dispensaries, fellow users, or cops call it "pot". Nobody does unless he thinks it is a big thing.

Oh. So you're a "legitimate" pot smoker, then?
C'mon George. It's a colloquialism used by a large cross section of people.
yankee2
2.4 / 5 (7) Jul 04, 2016
Captain Stumpy: You "just don't agree that it's safe to drive on?" I don't think you have any evidence that it's not. You are extrapolating from alcohol, an entirely different, and much more dangerous drug, from the perspective of driving (alcohol makes drivers reckless; cannabis makes drivers cautious - vastly different effect with respect to safety). Of course nothing is perfectly safe, and I will admit that newbies, either to driving or toking may be a source of issues, but for most of us with some experience, I say usually it is NOT. I believe your "science" is of the biased kind, of which billions of dollars worth have been commissioned by the US government. The studies I believe to be sound (and I am a retired pharmaceutical scientist, and believe I know the difference) tell us something quite different.
yankee2
3.3 / 5 (7) Jul 04, 2016
gkam: "It is cannabis, and if you had any experience with it, you would not call it "pot", the sign of a goober who has no experience of his own but blabbers as if he did?"

"Pot" is what almost everyone I ever knew who smoked cannabis called it, informally, including many now who have been smoking it for 50 years. Yes, we also call it "marijuana" and "cannabis," when we feel like it! Are you telling us that people who have been smoking POT almost daily for 50 years lack "experience with it?" That we don't know what it should be called? LOLOL!!! It is you my sad friend who seem to lack experience. You are far too rigid! It is YOU whom almost everyone here knows to be the goober...
yankee2
3 / 5 (6) Jul 04, 2016
yahroon: "It surely is proven BAD for your brain if you have a sensitivity in the schizofrenic disorder.
It can even cause psychosis
It for sure enhances paranoid thoughts and can induce psychotic thoughts and behaviour
Just visit a psychiatric center and ask about their thousands of examples in real life.
It is like a mega practical experimentation center.
It also is proven bad for you short term memory, so perhaps it is all about dose?"

Cannabis COULD precipitate a psychiatric episode in people who have psychiatric issues, but it does NOT cause them. Marijuana does NOT cause psychosis. It does infamously cause some paranoia, but that is also the same effect which makes driving stoned safe... it makes us cautious. That effect is NOT a problem for most of us. "It is proven bad for short-term memory?" Well, I studied for all 3 of my college degrees stoned, and I did very well, GPA-wise, in college. Cannabis did not seem to interfere with MY short-term memory.
yankee2
3.3 / 5 (7) Jul 04, 2016
gkam: "Go to Weedmaps and look at the delivery services in the East Bay of Northern CA."

You may not be aware of this, but there is a recent trend, particularly in the marijuana industry, to call it "cannabis," because that term is perceived as being more formal and respectable, for businesses which are trying everything to be taken seriously. I know that Harborside Healthcare in San Francisco is adament about calling pot "cannabis." Nevertheless, "pot" is not only an acceptable term, especially in casual conversation, it is THE single most common, widely used and traditional informal term for that drug, aka "cannabis" and "marijuana."
Captain Stumpy
3.9 / 5 (7) Jul 04, 2016
is not a big "f*cking" deal
@yep
agreed

.

.

I don't think you have any evidence
@yankee
WTF?
you mean besides the 7 validated studies i linked above?
really?
You are extrapolating from alcohol
nope. read the studies again
Yep's study was a combo study of alcohol and pot
i simply pointed out that "cannabis affects motor function" as noted in several validated studies
https://scholar.google.com

perhaps you should re-read what i wrote and reference those studies?
I believe your "science" is of the biased kind
1- just because you believe doesn't mean it is

2- feel free to refute the studies
provide evidence in the equivalent form i have to refute "my science"
IOW- validated peer reviewed studies
not "i believe" or anecdote

for every anecdote you have about how safe you are, i have ten you can look up in log-books for how dangerous DUI pot is
Protoplasmix
4.3 / 5 (6) Jul 04, 2016
posting problems...

edit - can't paste the post, this has never happened before...
Protoplasmix
4.3 / 5 (6) Jul 04, 2016
Still couldn't paste it like I always do, after repeated attempts. It's on pastebin now:
http://pastebin.com/hUcTt3dM
ThunderDolts
Jul 04, 2016
This comment has been removed by a moderator.
gkam
1 / 5 (7) Jul 04, 2016
Superficiality? I sent you to a real site, with news that you folk are not as cool as you think. How many delivery sites in the East Bay? Are you unaware of the culture, here for 50 years? It is the culture which invented Tomorrow, where cannabis users are everywhere, and half our progress was achieved on it. Silicon Valley? What do you think?

"Pot"? Is that what you folk really call it?
Uncle Ira
4.5 / 5 (8) Jul 04, 2016
Somehow "cannabishead" does not have the same ring to it. Plus the speller checker does not like that one. I vote for sticking with the "pothead".
gkam
1 / 5 (6) Jul 04, 2016
Yeah, you guys also call folk with college educations "pointy-heads".

Got plaque?
TheGhostofOtto1923
4.4 / 5 (7) Jul 04, 2016
Oh. So you're a "legitimate" pot smoker, then?
C'mon George. It's a colloquialism used by a large cross section of people
Yeah and BTW is it soda or pop? Let's ask an anal-retentive psychopath for the correct answer.
http://www.highti...spensary
gkam
1.6 / 5 (7) Jul 04, 2016
From protoplasmic:

"Ignoring history and science makes for pawns and dupes Friendly note to the DrugWarmongers:

You don't appear to have the law of the land on your side – because you're circumventing it. You obviously don't have science on your side, and the above article is yet another glaring example. And if you happen to exercise religion, you don't even have the god who created the plants, and who "has generously given us everything for our enjoyment," on your side. I'd GTFO as fast as I could if I were you."

posted without the references
Whydening Gyre
4.4 / 5 (7) Jul 04, 2016
Yeah, you guys also call folk with college educations "pointy-heads".

Got plaque?

Actually, I call them better educated (altho, not necessarily any smarter) PEOPLE (not 'folk").

Was your ? about plaque referring to "lowered incidence of Alzheimers related protein plaques in pot-smokers" kind of plaque?
And the "paranoia" factor is (IMO) a nurtured characteristic due to all the noise generated by all our exposure to how "dangerous" it is (ie - "Reefer Madness"). Not to mention the draconian measures taken to ensure we know it's illegal by government enforcement officials.
Uncle Ira
4.1 / 5 (9) Jul 04, 2016
Yeah, you guys also call folk with college educations "pointy-heads".
I never did call you a "pointy-head". And don't think I will get the urge to anytime soon. But then I also don't see many college educated people wearing silly looking pointy caps (with the stars and moons on him) either to try to instill confidence in potential marks, oops, I mean customers.

Got plaque?
What's it too you if I got plaques? You are the one who needs to brag on the awards and diplomas he never had. Oh yeah, you did win the monthly Air Force airman prize. (He must have made a lot peoples "jealous" and "envious" and "threatened" because it was suggested he leave early.)
Protoplasmix
4.2 / 5 (5) Jul 04, 2016
Re last post: It was pretty strange, I'd click submit and the text cursor would disappear and nothing would happen. Had plenty of characters to spare. Then I started getting "too many requests" errors from the server. Always refreshed the page before trying again. Logged out and back in, closed the browser, opened a new one. At one point I got some "administrative denial" message and couldn't even access phys.org – I thought I got banned.

Anyway, the above article is awesome news. Mom's late stage. Namzeric (memantine HCl and donepezil HCl) has done well delaying the progression, but not much to reverse it. Bad news is Mom lives in New York:
Marijuana is classified as a Schedule I substance in New York, which means that it has a high potential for abuse and no generally recognized medical value.
Ref

The draconian corruption needs to end, it's the 21st century already.
KaFaraqGatri
Jul 06, 2016
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