M-CSF plays role in host defense in bacterial pneumonia

M-CSF plays role in host defense in bacterial pneumonia

(HealthDay)—The cytokine M-CSF promotes survival of lung and liver mononuclear phagocytes to mediate host defense during bacterial pneumonia, according to an experimental study published in the June 15 issue of The Journal of Immunology.

Noting that M-CSF has multiple effects on mononuclear phagocytes, Alexandra Bettina, from the University of Virginia in Charlottesville, and colleagues examined the role of M-CSF during in a murine model.

The researchers observed reduced survival, increased bacterial burden, and greater lung injury with genetic deletion or immunoneutralization of M-CSF. M-CSF was also essential for lung mononuclear phagocyte expansion during infection, but had no effect on the number of bone marrow or blood monocytes, precursor proliferation, or leukocyte recruitment to the lungs. However, during pneumonia, M-CSF was necessary for survival and antimicrobial functions of and liver mononuclear phagocytes; bacterial dissemination to the liver and hepatic necrosis were seen in its absence.

"We conclude that M-CSF is critical to host defenses against bacterial pneumonia by mediating survival and antimicrobial functions of mononuclear in the lungs and liver," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

Journal information: Journal of Immunology

Copyright © 2016 HealthDay. All rights reserved.

Citation: M-CSF plays role in host defense in bacterial pneumonia (2016, August 4) retrieved 4 December 2023 from https://medicalxpress.com/news/2016-08-m-csf-role-host-defense-bacterial.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Pneumonia discovery may offer way to boost body's defenses


Feedback to editors