Comorbidity factors identified for exacerbation-prone asthma

September 1, 2016

(HealthDay)—Factors that are associated with exacerbation-prone asthma (EPA) have been identified, with blood eosinophils, body mass index, and bronchodilator responsiveness associated with exacerbation frequency, according to a study published online Aug. 24 in the American Journal of Respiratory and Critical Care Medicine.

Loren C. Denlinger, M.D., Ph.D., from the University of Wisconsin in Madison, and colleagues examined the clinical, physiological, inflammatory, and comorbidity factors associated with EPA. Patients were classified by the number of exacerbations in the previous year.

The researchers found that 41 percent of the 709 subjects in the National Heart, Lung, and Blood Institute Severe Asthma Research Program (SARP)-3 cohort had no exacerbations and 24 percent were exacerbation prone in the previous year. In SARP-3, factors normally associated with severity (asthma duration, age, sex, race, and socioeconomic status) were not associated with exacerbation frequency; bronchodilator responsiveness differentiated exacerbation proneness from severity. There were positive associations for eosinophils, , and bronchodilator responsiveness with exacerbation frequency in the SARP-3 multivariable model. Even after adjustment for multiple factors, chronic sinusitis and gastroesophageal reflux were also associated with exacerbation frequency. In the SARP 1 + 2 multivariable model, these effects were replicated.

"EPA may be a distinct susceptibility phenotype with implications for the targeting of exacerbation prevention strategies," the authors write.

Explore further: Considerable health care system burden for undiagnosed COPD

More information: Full Text (subscription or payment may be required)

Related Stories

Considerable health care system burden for undiagnosed COPD

August 15, 2016
(HealthDay)—The overall health system burden of exacerbations in patients with undiagnosed chronic obstructive pulmonary disease (COPD) is considerable, according to a study published in the Aug. 1 issue of the American ...

Vitamin D deficiency ups odds of asthma exacerbation

December 5, 2014
(HealthDay)—Vitamin D deficiency is associated with increased odds of asthma exacerbations, according to a study published in the December issue of Allergy.

Markers that predict omalizumab response identified

May 2, 2016
(HealthDay)—Baseline serum periostin levels and levels of serum free immunoglobulin E (IgE) during treatment follow-up may be useful in assessing response to omalizumab treatment for asthma, according to a study published ...

ATS: Indacaterol-glycopyrronium cuts COPD exacerbations

May 16, 2016
(HealthDay)—For patients with a history of chronic obstructive pulmonary disease (COPD) exacerbations, indacaterol-glycopyrronium is more effective for prevention of exacerbations than salmeterol-fluticasone, according ...

Depression ups readmission odds for COPD exacerbation

December 3, 2015
(HealthDay)—Depression is independently associated with increased risk of readmission for acute exacerbation of chronic obstructive pulmonary disease (COPD), according to a study published online Nov. 24 in the Annals of ...

'Obesity paradox': Extra weight linked to better outcomes for septic shock, asthma exacerbation

October 22, 2012
Although obesity is linked to a variety of health risks, new research indicates that obese patients may have an advantage over nonobese patients in certain health situations, including septic shock and acute asthma exacerbation.

Recommended for you

Chronic inflammation causes loss of muscle mass during aging

January 12, 2018
People start losing muscle mass at the age of 40—about some 10 percent of the total muscle mass for each 10-year period, which may lead to fall-related injuries, slowing metabolism and reduced quality of life. Today, very ...

Breathing exercises help asthma patients with quality of life

December 13, 2017
A study led by the University of Southampton has found that people who continue to get problems from their asthma, despite receiving standard treatment, experience an improved quality of life when they are taught breathing ...

Study highlights the need for research into prevention of inflammatory bowel disease

December 7, 2017
Countries in Africa, Asia, the Middle East and South America have seen a rise in incidence of inflammatory bowel disease as they have become increasingly industrialised and westernised, a new study has found.

Air pollution can increase asthma risk in adults, even at low levels

November 24, 2017
Living close to a busy road can be bad for your respiratory health if you are middle aged, new Australian research has found.

Evidence found of oral bacteria contributing to bowel disorders

October 20, 2017
(Medical Xpress)—An international team of researchers has found evidence that suggests certain types of oral bacteria may cause or exacerbate bowel disorders. In their paper published in the journal Science, the group describes ...

New compound discovered in fight against inflammatory disease

September 22, 2017
A 10-year study by University of Manchester scientists for a new chemical compound that is able to block a key component in inflammatory illness has ended in success.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.