Resveratrol can help to reduce inflammation, study finds

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A component of red wine and grapes can help control inflammation induced by a bacterial pathogen that is linked to upper respiratory tract inflammatory diseases such as asthma, chronic obstructive pulmonary diseases (COPD) and middle ear infection (otitis media), according to a study by researchers at Georgia State University.

The findings, published in the online journal Scientific Reports, identify a novel mechanism that , a compound found naturally in some plant foods such as grapes, uses to alleviate in . The results suggest this compound could offer health benefits and be used to develop new, effective anti-inflammatory therapeutic agents.

"We showed that an important component in red wine and also grapes called resveratrol can suppress inflammation," said Dr. Jian-Dong Li, a senior author of the study, director of the Institute for Biomedical Sciences at Georgia State and a Georgia Research Alliance Eminent Scholar. "It has been shown that resveratrol can suppress inflammation, but how it regulates inflammation still remains largely unknown. We found that resveratrol suppresses a major causing otitis media and COPD by upregulating or increasing the production of a negative regulator called MyD88 short."

Resveratrol belongs to a group of compounds called polyphenols that are thought to act like antioxidants and protect the body against damage. It has long been considered a therapeutic agent for various diseases, including inflammatory diseases. In the study, resveratrol was effective against inflammation caused by nontypeable Haemophilus influenzae (NTHi), a major respiratory pathogen.

An appropriate amount of inflammation in the body is beneficial for defense against bacterial infection, but uncontrolled inflammation leads to inflammatory diseases. Upper respiratory tract such as asthma and COPD affect more than half a billion people worldwide and are characterized by that is aggravated by respiratory pathogens such as NTHi. Asthma results in 250,000 deaths annually and is the leading cause of hospitalizations in children younger than 15 in the United States. COPD is the third leading cause of death in the U.S., and the World Health Organization predicts it will be the fifth most significant contributor to worldwide disease by 2020. Otitis media is the most common bacterial infection and also the leading cause of conductive hearing loss in children.

Antibiotics are routinely used to treat NTHi infections, but the increasing numbers of antibiotic-resistant bacterial strains and the limited success of currently available pharmaceuticals used to manage the symptoms of these diseases present an urgent need for the development of non-antibiotic therapeutics.

This study found for the first time that resveratrol decreases NTHi-induced expression of pro-inflammatory mediators in airway epithelial cells and in the lungs of mice by enhancing MyD88 short, a negative regulator of inflammatory signaling pathways. MyD88 short is considered a "brake pedal protein" because it can tightly control inflammation induced by this respiratory pathogen. It could be a critical target with significant therapeutic potential for suppressing inflammation associated with chronic airway disease.

The researchers also found that resveratrol has anti-inflammatory effects after NTHi infection, which demonstrates its therapeutic potential.

"The findings help us to shed light on developing new therapeutic strategies by targeting or pharmacologically upregulating MyD88 short production," Li said. "We could use resveratrol to suppress inflammation or develop resveratrol derivatives that could be pharmacological agents to suppress inflammation using the same strategy."


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Body tightly controls inflammatory response to pathogens, study finds

Journal information: Scientific Reports

Citation: Resveratrol can help to reduce inflammation, study finds (2016, September 28) retrieved 19 June 2019 from https://medicalxpress.com/news/2016-09-resveratrol-inflammation.html
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Sep 28, 2016
This is the same old pseudo-science that has repeatedly been debunked again and again. There is NO conclusive evidence of health benefit from Resveratrol and generally extremely little health benefit if any from antioxidants.
see, for example;
http://www.medpag...gy/45738
Please don't be conned by the food industry and marketers.

Sep 28, 2016
humy, totally agree. Also, mentioning alcohol as one of the carriers of resveratrol, and a photo of a wine glass, is almost a giveaway of the study having some link to wine industry funding. Minuscule amount of resveratrol in wine would be not enough, even if resveratrol had any effect.There is coincidentally one of the countless studies of harm from even moderate consumption of alcohol, just today:
http://medicalxpr...ber.html
Heart attack probability increase caused by alcohol, in this one.

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