Alzheimer's disease proteins could be at fault for leading cause of vision loss among older people

November 21, 2016
eye

Research from the University of Southampton gives new insight into possible causes of age-related macular degeneration (AMD), a leading cause of vision loss among people aged 50 and older.

The study, published in the journal Experimental Eye Research, discovered that a group of proteins, which are linked to Alzheimer's disease, are able to accumulate in the and damage it.

The researchers hope that the discovery could lead to better treatments for patients.

AMD is a progressive disease that causes the death of the retinal photoreceptors, the light-sensitive cells at the back of the eye. The most severe damage occurs in the macula, a small area of the retina that is needed for sharp, central vision necessary for reading, driving and other daily tasks.

There are two different types of AMD – 'wet' and 'dry'. In wet AMD, the growth of leaky blood vessels which damage the retina can be stopped.. However, this does not work for everyone, and is a way to manage rather than cure wet AMD. By contrast, dry AMD has no approved treatment as yet.

Dr Arjuna Ratnayaka, a Lecturer in Vision Sciences at the University of Southampton, who led the study, said: "We know that AMD is caused by a combination of genetic, environmental and , but this novel discovery could open up new possibilities to understand how the ageing retina becomes damaged. Such advances are important if we are to develop better AMD treatments in the future.

"AMD currently affects more than 600,000 people in the UK and 50 million individuals worldwide. This figure is expected rise significantly as our society grows older. We urgently need new treatments to stop people spending their twilight years in blindness."

The study, which used both cell cultures and mouse models, analysed how quickly Amyloid beta proteins, which are thought to be a likely cause of Alzheimer's disease, entered the retina and how they damaged it.

The team found that the Amyloid beta proteins entered the cells of the retina within 24 hours of exposure and then began to break the cell's scaffold structure.

Dr Ratnayaka added: "The speed in which these proteins entered the was unexpected. These findings have given some insights into how a normal healthy retina can switch to a diseased AMD retina. We hope that this could lead to designing better treatments for patients in the future."

The research team's next step will be to evaluate how the Amyloid beta proteins get into retinal cells and study more closely how damage occurs, with a view of establishing preventative measures or treatment options.

Explore further: Genetic mutations that lead to macular degeneration blindness mapped by new research

More information: George Taylor-Walker et al. The Alzheimer's-related amyloid beta peptide is internalised by R28 neuroretinal cells and disrupts the microtubule associated protein 2 (MAP-2), Experimental Eye Research (2016). DOI: 10.1016/j.exer.2016.10.013

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