Metabolic benefit same with similar weight loss after surgery

Metabolic benefit same with similar weight loss after surgery

(HealthDay)—Early metabolic differences following laparoscopic adjustable gastric banding (LAGB) and Roux-en-Y gastric bypass (RYGB) in obese individuals with type 2 diabetes mellitus (T2DM) disappear when weight loss reaches 20 percent, regardless of surgery type, according to a study published online Nov. 8 in Diabetes Care.

Marlena M. Holter, from Columbia University in New York City, and colleagues examined the effect of RYGB and LAGB on metabolic parameters in patients matched on small and large amounts of weight loss. Severely with T2DM were tested for , β-cell function, and after oral and intravenous glucose stimuli, before and one year after RYGB and LAGB, and at 10 and 20 percent weight loss after surgery.

The researchers found that RYGB resulted in greater glucagon-like peptide 1 release and incretin effect versus LAGB, at any level of weight loss. At 10 percent weight loss, RYGB decreased glucose levels (120 minutes and area under the curve for glucose) more than LAGB. However, after 20 percent equivalent weight loss, the improvement in glucose metabolism, the rate of diabetes remission and use of diabetes medications, insulin sensitivity, and β-cell function were similar after the two types of surgery.

"Although RYGB retained its unique effect on incretins, the superiority of the effect of RYGB over that of LAGB on glucose metabolism, which is apparent after 10 percent weight loss, was attenuated after larger ," the authors write.


Explore further

Rapid improvement in insulin sensitivity with bariatric surgery

More information: Full Text (subscription or payment may be required)
Journal information: Diabetes Care

Copyright © 2016 HealthDay. All rights reserved.

Citation: Metabolic benefit same with similar weight loss after surgery (2016, November 21) retrieved 9 December 2019 from https://medicalxpress.com/news/2016-11-metabolic-benefit-similar-weight-loss.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
0 shares

Feedback to editors

User comments