Longer-term follow-up shows greater type 2 diabetes remission for bariatric surgery compared to life

Among obese participants with type 2 diabetes mellitus, bariatric surgery with 2 years of a low-level lifestyle intervention resulted in more disease remission than did lifestyle intervention alone, according to a study published online by JAMA Surgery.

It remains to be established whether is a durable and effective treatment for type 2 diabetes (T2DM) and how bariatric surgery compares with intensive and medication management with respect to T2DM-related outcomes. As demonstrated in observational studies and several small of short duration, T2DM is greatly improved after bariatric surgery. However, more information is needed about the longer-term effectiveness and risks of all types of bariatric surgical procedures compared with lifestyle and medical management for those with T2DM and obesity, according to background information in the article.

Anita P. Courcoulas, M.D., M.P.H., of the University of Pittsburgh Medical Center, Pittsburgh, and colleagues assessed outcomes 3 years after 61 obese with T2DM who were randomly assigned to either an intensive lifestyle intervention for 1 year followed by a low-level for 2 years or surgical treatments (Roux-en-Y gastric bypass [RYGB] or laparoscopic adjustable gastric banding [LAGB]) followed by low-level lifestyle intervention in years 2 and 3. Fifty participants (82 percent) were women, and 13 (21 percent) were African American.

At 3 years, any T2DM remission (partial or complete) was achieved in 40 percent (n = 8) of RYGB, 29 percent (n = 6) of LAGB, and no intensive lifestyle weight loss intervention participants, while complete remission was achieved in 15 percent of RYGB, 5 percent of LAGB, and no intensive lifestyle weight loss intervention group participants.

The use of diabetes medications was reduced more in the surgical groups than the lifestyle intervention-alone group, with 65 percent of RYGB, 33 percent of LAGB, and none of the intensive lifestyle weight loss intervention participants going from using insulin or oral medication at baseline to no medication at year 3. Average reductions in percentage of body weight at 3 years were the greatest after RYGB at 25 percent (2 percent), followed by LAGB at 15 percent (2 percent) and lifestyle treatment at 5.7 percent (2.4 percent).

The authors note that one important aspect of this study was that more than 40 percent of the sample were individuals with class I obesity (BMI of 30 to <35) for whom data in the literature are largely lacking. "Those who underwent a surgical procedure followed by low-level lifestyle intervention were significantly more likely to achieve and maintain glycemic control than were those who received intensive and then maintenance (low-level) lifestyle therapy alone, regardless of obesity class. More than two-thirds of those in the RYGB group and nearly half of the LAGB group did not require any medications for T2DM treatment at 3 years."

"This study provides further important evidence that at longer-term follow-up of 3 years, surgical treatments, including RYGB and LAGB, are superior to lifestyle intervention alone for the remission of T2DM in obese individuals including those with a BMI between 30 and 35. While this trial provides valuable insights, unanswered questions remain such as the impact of these treatments on long-term microvascular and macrovascular complications and the precise mechanisms by which bariatric surgical procedures induce their effects."

In a related commentary, Michel Gagner, M.D., F.R.C.S.C., F.A.S.M.B.S., of Florida International University, Miami, writes: "We should consider the use of bariatric (metabolic) in all severely obese patients with T2DM and start a mass treatment, similar to what was done with coronary artery bypass graft more than 50 years ago."


Explore further

Two JAMA Surgery studies examine bariatric surgery for type 2 diabetes treatment

More information: JAMA Surgery. Published online July 1, 2015. DOI: 10.1001/jamasurg.2015.1534

JAMA Surgery. Published online July 1, 2015. DOI: 10.1001/jamasurg.2015.1542

Journal information: JAMA Surgery

Citation: Longer-term follow-up shows greater type 2 diabetes remission for bariatric surgery compared to life (2015, July 1) retrieved 24 August 2019 from https://medicalxpress.com/news/2015-07-longer-term-follow-up-greater-diabetes-remission.html
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