Inflammatory markers prognostic in primary sinonasal cancer

January 10, 2017

(HealthDay)—Pretreatment neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) can predict survival for patients with primary sinonasal cancers (SNCs), according to a study published online Dec. 29 in Head & Neck.

Mario Turri-Zanoni, M.D., from the University of Insubria in Varese, Italy, and colleagues conducted a of patients with SNC who had been treated using endoscopic approaches from 2002 to 2014. They examined the value of NLR and PLR in predicting and mortality for 215 patients.

The researchers found that in analysis of (adenocarcinoma and carcinoma) and advanced-stage tumors (pT3-T4), patients with higher NLR and PLR had shorter overall and disease-free survival. NLR and PLR were independent prognostic factors for disease-free survival, with the risk of recurrence reduced among with NLR <2.6 and PLR <156.9 (hazard ratios, 0.39 and 0.34, respectively).

"In conclusion, this study demonstrates that systemic inflammatory serum markers at presentation may be used as predictors of mortality and recurrence for advanced-stage epithelial paranasal sinus cancers," the authors write. "Future studies are needed to better understand inflammatory response mechanisms in such a rare and aggressive disease."

Explore further: Hematologic markers predict nasopharyngeal cancer survival

More information: Full Text (subscription or payment may be required)

Related Stories

Hematologic markers predict nasopharyngeal cancer survival

September 22, 2015
(HealthDay)—Pretreatment neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) may be predictors for survival in nasopharyngeal carcinoma, according to a study published online Sept. 11 in Head & Neck.

Type of treatment impacts recurrence in laryngeal SCC

December 14, 2016
(HealthDay)—For patients with laryngeal squamous cell carcinoma (SCC), factors predictive of recurrence include neck metastasis at presentation and nonsurgical treatment, according to a study published online Nov. 30 in ...

Oct4 found to be a prognostic marker for digestive cancers

November 22, 2016
(HealthDay)—Octamer-binding transcription factor 4 (Oct4) is a predictive marker for patients with digestive system cancers, according to a review and meta-analysis published online Nov. 7 in the Journal of Gastroenterology ...

Endoscopic management viable for sinonasal schwannomas

February 19, 2016
(HealthDay)—Endoscopic management is feasible for sinonasal schwannomas, according to research published online Feb. 15 in Head & Neck.

Ipilimumab as adjuvant therapy improves overall survival in high risk stage III melanoma

October 8, 2016
Ipilimumab as adjuvant therapy significantly improves overall survival in patients with high risk stage III melanoma, according to the EORTC 18071 phase III trial results presented for the first time today at the ESMO 2016 ...

Diabetes predicts worse survival in renal cell carcinoma

November 19, 2015
(HealthDay)—Diabetes mellitus is associated with worse prognosis in terms of progression-free, overall, and cancer-specific survival in patients with renal cell carcinoma treated surgically, according to a study published ...

Recommended for you

Stem cell therapy attacks cancer by targeting unique tissue stiffness

July 26, 2017
A stem cell-based method created by University of California, Irvine scientists can selectively target and kill cancerous tissue while preventing some of the toxic side effects of chemotherapy by treating the disease in a ...

Understanding cell segregation mechanisms that help prevent cancer spread

July 26, 2017
Scientists have uncovered how cells are kept in the right place as the body develops, which may shed light on what causes invasive cancer cells to migrate.

Study uncovers potential 'silver bullet' for preventing and treating colon cancer

July 26, 2017
In preclinical experiments, researchers at VCU Massey Cancer Center have uncovered a new way in which colon cancer develops, as well as a potential "silver bullet" for preventing and treating it. The findings may extend to ...

Compound shows promise in treating melanoma

July 26, 2017
While past attempts to treat melanoma failed to meet expectations, an international team of researchers are hopeful that a compound they tested on both mice and on human cells in a petri dish takes a positive step toward ...

Study may explain failure of retinoic acid trials against breast cancer

July 25, 2017
Estrogen-positive breast cancers are often treated with anti-estrogen therapies. But about half of these cancers contain a subpopulation of cells marked by the protein cytokeratin 5 (CK5), which resists treatment—and breast ...

Breaking the genetic resistance of lung cancer and melanoma

July 25, 2017
Researchers from Monash University and the Memorial Sloan Kettering Cancer Center (MSKCC, New York) have discovered why some cancers – particularly lung cancer and melanoma – are able to quickly develop deadly resistance ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.