Inflammatory markers prognostic in primary sinonasal cancer

January 10, 2017

(HealthDay)—Pretreatment neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) can predict survival for patients with primary sinonasal cancers (SNCs), according to a study published online Dec. 29 in Head & Neck.

Mario Turri-Zanoni, M.D., from the University of Insubria in Varese, Italy, and colleagues conducted a of patients with SNC who had been treated using endoscopic approaches from 2002 to 2014. They examined the value of NLR and PLR in predicting and mortality for 215 patients.

The researchers found that in analysis of (adenocarcinoma and carcinoma) and advanced-stage tumors (pT3-T4), patients with higher NLR and PLR had shorter overall and disease-free survival. NLR and PLR were independent prognostic factors for disease-free survival, with the risk of recurrence reduced among with NLR <2.6 and PLR <156.9 (hazard ratios, 0.39 and 0.34, respectively).

"In conclusion, this study demonstrates that systemic inflammatory serum markers at presentation may be used as predictors of mortality and recurrence for advanced-stage epithelial paranasal sinus cancers," the authors write. "Future studies are needed to better understand inflammatory response mechanisms in such a rare and aggressive disease."

Explore further: Hematologic markers predict nasopharyngeal cancer survival

More information: Full Text (subscription or payment may be required)

Related Stories

Hematologic markers predict nasopharyngeal cancer survival

September 22, 2015

(HealthDay)—Pretreatment neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) may be predictors for survival in nasopharyngeal carcinoma, according to a study published online Sept. 11 in Head & Neck.

Type of treatment impacts recurrence in laryngeal SCC

December 14, 2016

(HealthDay)—For patients with laryngeal squamous cell carcinoma (SCC), factors predictive of recurrence include neck metastasis at presentation and nonsurgical treatment, according to a study published online Nov. 30 in ...

Oct4 found to be a prognostic marker for digestive cancers

November 22, 2016

(HealthDay)—Octamer-binding transcription factor 4 (Oct4) is a predictive marker for patients with digestive system cancers, according to a review and meta-analysis published online Nov. 7 in the Journal of Gastroenterology ...

Diabetes predicts worse survival in renal cell carcinoma

November 19, 2015

(HealthDay)—Diabetes mellitus is associated with worse prognosis in terms of progression-free, overall, and cancer-specific survival in patients with renal cell carcinoma treated surgically, according to a study published ...

Recommended for you

Ancient stress response provides clues to cancer resistance

April 25, 2017

Cancer is often able to craftily outwit the best techniques modern medicine has developed to treat it. In an attempt to understand and combat cancer's vaunted prowess, an unusual collaboration between physicists and a leading ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.