In T2DM, bariatric surgery ups splanchnic vascular responses

In T2DM, bariatric surgery ups splanchnic vascular responses

(HealthDay)—For obese patients with type 2 diabetes (T2D), bariatric surgery is associated with improved splanchnic vascular responses, according to a study published online Jan. 17 in Diabetes.

Henri Honka, from the University of Turku in Finland, and colleagues characterized the vascular effects of a mixed-meal and of infusion of exogenous glucose-dependent insulinotropic polypeptide (GIP) in the splanchic region in 10 lean controls and 10 with T2D before and after . At baseline, 20, and 50 minutes, they measured pancreatic and intestinal blood flow (BF) with 15O-water using and .

The researchers found that there was no difference between obese and lean controls in terms of pancreatic and intestinal BF responses to a mixed-meal before surgery. The mixed-meal induced greater increase in plasma glucose, insulin, and GIP concentrations after surgery compared with before surgery, which was accompanied by an increase in pancreatic and intestinal BF responses. Both before and after surgery, GIP infusion decreased pancreatic but increased small intestinal BF similarly in all groups.

"Taken together, these results demonstrate that bariatric surgery leads to enhanced splanchnic vascular responses, most likely as a consequence of rapid glucose appearance and GIP hypersecretion," the authors write.


Explore further

Rapid improvement in insulin sensitivity with bariatric surgery

More information: Full Text (subscription or payment may be required)
Journal information: Diabetes

Copyright © 2017 HealthDay. All rights reserved.

Citation: In T2DM, bariatric surgery ups splanchnic vascular responses (2017, January 25) retrieved 4 August 2020 from https://medicalxpress.com/news/2017-01-t2dm-bariatric-surgery-ups-splanchnic.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
0 shares

Feedback to editors

User comments