Use of opioid pain medications may affect liver transplant patients' survival

An analysis of nearly 30,000 patients undergoing liver transplantation in the United States between 2008 and 2014 found elevated death and organ loss rates in the first 5 years after transplantation among recipients with the highest use of opioid pain medications while on the waiting list.

Higher risks mainly emerged after the first transplant anniversary, a pattern that may in part reflect sustained opioid use. Sixty five percent of those with the highest level of opioid use on the continued moderate to high level use in the first year after transplantation.

The findings indicate that who require high levels of opioids should be carefully assessed and monitored before and after transplantation.

"Concerns for an epidemic of complications related to use of has not spared the population with end-stage liver disease" said Dr. Krista Lentine, senior author of the Liver Transplantation study. "Risks of opioid-related toxicities may be even greater in patients with organ failure, due to altered drug metabolism and excretion. More work is needed to identify underlying mechanisms of mortality, determine the impact of decreasing opioid use before transplant, and design pain management strategies that improve patient outcomes."

More information: Henry B. Randall et al. Survival implications of opioid use before and after liver transplantation, Liver Transplantation (2017). DOI: 10.1002/lt.24714

Journal information: Liver Transplantation
Provided by Wiley
Citation: Use of opioid pain medications may affect liver transplant patients' survival (2017, March 2) retrieved 20 February 2024 from
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