Some benefit for curcuminoids in knee osteoarthritis
Igho J. Onakpoya, M.D., from the University of Oxford in the United Kingdom, and colleagues reviewed data from randomized controlled trials that examined the effectiveness of orally-administered curcuminoids in OA in adults. Data were included from seven studies conducted in Asia, with 797 participants with primarily knee OA.
The overall risk of bias in the studies was moderate. The researchers found that curcuminoids correlated with significantly reduced knee pain (standardized mean difference, − 3.45) and improved quality of life (mean difference, −2.69) compared with placebo. Compared with ibuprofen, curcuminoids had significantly fewer effects on pain relief, knee stiffness, and physical function. Curcuminoids also correlated with significant improvements in Western Ontario and McMaster Universities Arthritis Index total scores and with significant reductions in rescue medication use. There were no serious adverse events.
"Curcuminoids may have some beneficial effects on knee pain and quality of life in patients with knee OA," the authors write. "However, they are less effective at relieving pain compared with ibuprofen."
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