Multidrug-resistant TB set to increase through 2040

May 11, 2017

(HealthDay)—Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis are expected to increase through 2040, according to a study published online May 9 in The Lancet Infectious Diseases.

Aditya Sharma, M.D., from the U.S. Centers for Disease Control and Prevention in Atlanta, and colleagues calibrated a compartmental model to data from surveys and World Health Organization tuberculosis reports to forecast estimates of incident MDR and XDR tuberculosis in India, the Philippines, Russia, and South Africa from 2000 to 2040.

The researchers found that the percentage of MDR tuberculosis among incident cases of tuberculosis was forecast to increase, reaching 12.4, 8.9, 32.5, and 5.7 percent in India, the Philippines, Russia, and South Africa, respectively, in 2040. The percentage of XDR tuberculosis among incident MDR tuberculosis was also predicted to increase, reaching 8.9, 9.0, 9.0, and 8.5 percent in India, the Philippines, Russia, and South Africa, respectively, in 2040. During 2000 to 2040, acquired drug resistance was expected to cause less than 30 percent of incident MDR tuberculosis. In 2000, acquired drug resistance caused 80 percent of incident tuberculosis; by 2040, this is expected to decline to less than 50 percent.

"Additional control efforts beyond improving acquired drug resistance rates are needed to stop the spread of MDR and XDR tuberculosis in countries with a high burden of MDR ," the authors write.

Explore further: Curcumin may help overcome drug-resistant tuberculosis

More information: Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

Curcumin may help overcome drug-resistant tuberculosis

March 24, 2016
New research indicates that curcumin—a substance in turmeric that is best known as one of the main components of curry powder—may help fight drug-resistant tuberculosis. In Asia, turmeric is used to treat many health ...

Drug resistance-associated genes: A cornerstone for the control and protection against tuberculosis

September 5, 2013
BGI in collaboration with Institute of Biophysics, Chinese Academy of Sciences, and other Chinese institutes, have completed the genome sequencing of 161 Mycobacterium tuberculosis that can cause an infectious disease tuberculosis ...

Multidrug-resistant TB appears less transmissible in households than drug-susceptible TB

June 23, 2015
Some strains of multidrug resistant tuberculosis (MDRTB) may have a lower fitness (be less capable of spreading) than drug-susceptible tuberculosis bacteria, according to a study published this week in PLOS Medicine. The ...

Revealing the global burden of drug-resistant tuberculosis in children

June 27, 2016
A new study examining the burden of drug-resistant tuberculosis (TB) across the globe has highlighted the importance of the disease among children.

Researchers find a way to reverse antibiotic resistance in Mycobacterium tuberculosis

March 17, 2017
(Medical Xpress)—A team of researchers from Sweden, France, Belgium and Switzerland has found a way to reverse resistance to an antibiotic drug used to treat tuberculosis. In their paper published in the journal Science, ...

Potential new drug for tuberculosis

August 5, 2013
A new drug capable of inhibiting growth of Mycobacterium tuberculosis is reported this week in Nature Medicine. The findings may improve therapeutic options for the treatment of drug resistant tuberculosis (TB).

Recommended for you

Study identifies how hantaviruses infect lung cells

November 21, 2018
Hantaviruses cause severe and sometimes fatal respiratory infections, but how they infect lung cells has been a mystery. In today's issue of Nature, an international team including researchers at Albert Einstein College of ...

Scientists shed new light on infection process of the gastrointestinal pathogen C. difficile

November 21, 2018
Scientists from the VIB-UGent Center for Inflammation Research identified the mechanisms by which the bacterial pathogen Clostridium difficile kills intestinal epithelial cells (IECs), thus destroying the protective mucosal ...

As antibiotic resistance grows, researchers find new targets for fighting deadly staph infections

November 21, 2018
A new look at the inner-workings of bacterial cells could help researchers overcome deadly antibiotic resistance and save the lives of tens-of-thousands of people every year.

Can liver disease be linked to heart failure? Study highlights liver-heart interaction

November 21, 2018
Virginia Commonwealth University researchers have collaborated on a clinical trial that identifies indicators for nonalcoholic fatty liver disease—a typically asymptomatic disease caused by fat buildup in the liver and ...

Researchers find infectious prions throughout eyes of patients with deadly sporadic Creutzfeldt-Jakob disease

November 20, 2018
By the time symptoms of sporadic Creutzfeldt-Jakob disease (sCJD) are typically discovered, death is looming and inevitable. But, in a new study, researchers at University of California San Diego School of Medicine with colleagues ...

Researchers a step closer to understanding how deadly bird flu virus takes hold in humans

November 19, 2018
New research has taken a step towards understanding how highly pathogenic influenza viruses such as deadly bird flu infect humans.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.