Hypothermia after stroke reduces dynamin levels and neuronal cell death

A new study has shown that following brain ischemia caused by cerebral blockage in mice both immediate and delayed reduction in body temperature helped limit cell death and levels of a protein called dynamin. These results, which suggest that dynamin may have a role in—and be a potential drug target for—stroke-related neuronal cell death, are reported in Therapeutic Hypothermia and Temperature Management.

The article entitled "Hypothermia Identifies Dynamin as a Potential Therapeutic Target in Experimental Stroke" is coauthored by Jong Youl Kim, PhD, Nuri Kim, Jong Eun Lee, PhD, and Midori Yenari, MD, University of California, San Francisco and Yonsei University College of Medicine, Seoul, Republic of Korea.

The researchers demonstrated increased expression of and the cell surface receptor FAS in a mouse model of stroke. They assessed the effects of two cooling approaches on the survival of brain : cooling as soon as cerebral blockage occurs (early hypothermia) and cooling that began 1 hour later (delayed hypothermia). The results were compared to those in mice not subjected to .

"These exciting results present new injury pathways to target for utilizing in acute as well as sub-acute time points after stroke," says W. Dalton Dietrich, III, PhD, Editor-in-Chief of Therapeutic Hypothermia and Temperature Management, Scientific Director of The Miami Project to Cure Paralysis, and Kinetic Concepts Distinguished Chair in Neurosurgery, University of Miami Leonard M. Miller School of Medicine.


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More information: Jong Youl Kim et al, Hypothermia Identifies Dynamin as a Potential Therapeutic Target in Experimental Stroke, Therapeutic Hypothermia and Temperature Management (2017). DOI: 10.1089/ther.2017.0005
Citation: Hypothermia after stroke reduces dynamin levels and neuronal cell death (2017, August 16) retrieved 11 August 2020 from https://medicalxpress.com/news/2017-08-hypothermia-dynamin-neuronal-cell-death.html
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