Transforming skin cells to insulin

August 9, 2017

Researchers at the University of Bergen have transformed skin puncture cells from diabetes patients into insulin producing cells, using stem cell techniques. The researchers' aim is to transplant these cells under the skin of people with diabetes.

"This study is a step towards discovering how "stand-in" cells can secrete insulin in the body," says Professor Helge Ræder, leader of the stem cell node at the K.G. Jebsen Centre for Diabetes Research, University of Bergen.

Automatic insulin regulation

In the long run, the researchers´ goal is to replace insulin shots and blood sugar measurements with insulin-secreting cells capable of automatically secreting insulin in response to the . This can become possible by implanting a capsule with tailor made cells in each diabetes patient.

"Our study is a step further in the spare part or regenerative medicine, where a lot may go wrong but where a successful approach may cure diabetes," Ræder says.

Today, there is an ongoing race between scientists trying to restore within the human body in , by artificially created insulin-producing cells.

"There is a big marked out there for those who can commercialize successful treatment with this approach. Today 400 million people have diabetes worldwide," Professor Helge Ræder underlines.

Explore further: Insulin release is controlled by the amount of Epac2A at the secretory vesicles

More information: Heidrun Vethe et al, Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells, Scientific Reports (2017). DOI: 10.1038/s41598-017-04979-w

Related Stories

Insulin release is controlled by the amount of Epac2A at the secretory vesicles

July 7, 2017
Specialized beta cells in the pancreas release the hormone insulin to control our blood glucose levels, and failure of this mechanism is central to the development of type-2 diabetes. How much and when insulin is released ...

Mislocalized calcium channel causes insulin secretion defect in diabetes

May 19, 2017
Researchers from Uppsala University have studied beta cells of type-2 diabetic donors, and find that a mislocalized calcium channel contributes to the failed insulin secretion associated with the disease.

Diabetes researchers find faster way to create insulin-producing cells

September 11, 2014
University of British Columbia, in collaboration with BetaLogics Venture, a division of Janssen Research & Development, LLC, has published a study highlighting a protocol to convert stem cells into insulin-producing cells. ...

Stem cells from diabetic patients coaxed to become insulin-secreting cells

May 10, 2016
Signaling a potential new approach to treating diabetes, researchers at Washington University School of Medicine in St. Louis and Harvard University have produced insulin-secreting cells from stem cells derived from patients ...

Team cures diabetes in mice without side effects

May 5, 2017
A potential cure for Type 1 diabetes looms on the horizon in San Antonio, and the novel approach would also allow Type 2 diabetics to stop insulin shots.

Same gene links blood sugar problems in Down syndrome and Type 2 diabetes

May 19, 2016
Problems with insulin secretion experienced by people with Type 2 diabetes, parallel similar problems with insulin-secreting beta cells in many individuals with Down syndrome. A new study, published on May 19 in PLOS Genetics ...

Recommended for you

Smart mat detects early warning signs of foot ulcers

August 16, 2017
While completing his residency in anesthesiology at Massachusetts General Hospital in the mid-2000s, Jon Bloom saw his fair share of foot amputations among patients with diabetes. The culprit: infected foot ulcers.

The best place to treat type 1 diabetes might be just under your skin

August 14, 2017
A group of U of T researchers have demonstrated that the space under our skin might be an optimal location to treat type 1 diabetes (T1D).

New measure of insulin-making cells could gauge diabetes progression, treatment

August 10, 2017
Researchers at the University of Wisconsin-Madison have developed a new measurement for the volume and activity of beta cells, the source of the sugar-regulating hormone insulin.

Pioneering immunotherapy shows promise in type 1 diabetes

August 9, 2017
It may be possible to 'retrain' the immune system to slow the progression of type 1 diabetes, according to results of a clinical trial published today in the journal Science Translational Medicine.

Online team-based game helps patients with diabetes lower blood glucose

August 8, 2017
Researchers from Brigham and Women's Hospital and the Veterans Affairs Boston Healthcare System have found that an online, team-based game designed to teach patients about diabetes self-management had a sustained and meaningful ...

Oxidative stress biomarkers don't always signal diabetes risk

August 7, 2017
High levels of compounds found in the body that are commonly associated with oxidative damage may actually be a good sign for some people, according to a recent review of multiple human studies led by an epidemiologist at ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.