Mislocalized calcium channel causes insulin secretion defect in diabetes

May 19, 2017, Uppsala University

Researchers from Uppsala University have studied beta cells of type-2 diabetic donors, and find that a mislocalized calcium channel contributes to the failed insulin secretion associated with the disease.

After a meal, the blood sugar rises. To counteract this and to make the sugar available to the body, specialized cells in the pancreas get activated to secrete . In people with diabetes this mechanism fails, which leads to elevated blood sugar and a host of other diabetes related complications.

The cellular signal for is an influx of calcium, which triggers the release of small hormone-containing storage vesicles. Recent work from Sebastian Barg's lab at Uppsala University, in collaboration with researchers from Padua, Oxford, and the NIH, now indicates that a tiny change in the cells' architecture is at the heart of the secretion defect.

Using high resolution microscopy, the group found that calcium normally enters right next to the storage vesicle to trigger insulin release. In type-2 diabetes, the channel proteins that allow the entry are instead located too far away from the insulin vesicles, which causes secretion to fail. The findings offer a first glimpse at the intricate relationship between the insulin secretion machinery and , and suggests that drugs aimed at their interaction could be developed to treat diabetes.

Explore further: Vitamin D doesn't impact insulin sensitivity, secretion in T2DM

More information: Nikhil R. Gandasi et al. Ca2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetes, Journal of Clinical Investigation (2017). DOI: 10.1172/JCI88491

Related Stories

Vitamin D doesn't impact insulin sensitivity, secretion in T2DM

May 10, 2017
(HealthDay)—For patients with type 2 diabetes (T2D) and vitamin D deficiency, vitamin D supplementation has no impact on insulin sensitivity or secretion, according to a study published online May 3 in Diabetes Care.

Molecular aid to insulin secretion identified

February 17, 2017
Blood sugar triggers the secretion of insulin from cells in the pancreas, a process that is impaired in diabetes. A team of Yale researchers have identified a mechanism at the membranes of these pancreatic cells that controls ...

Insulin on demand: A biochemical explanation for the success of billion-dollar diabetes drugs

January 6, 2016
The protein targets of a class of 'blockbuster' diabetes drugs have been identified by A*STAR researchers and may help explain varying type-2 patient responses to the drugs.

Same gene links blood sugar problems in Down syndrome and Type 2 diabetes

May 19, 2016
Problems with insulin secretion experienced by people with Type 2 diabetes, parallel similar problems with insulin-secreting beta cells in many individuals with Down syndrome. A new study, published on May 19 in PLOS Genetics ...

Role of protein in pancreatic secretion suggests potential method for treating diabetes

December 8, 2016
Movement of secretory molecules, such as hormones and digestive enzymes, out of the cell is known as exocytosis. This process is guided by SNARE proteins, which help the fusion of secretory vesicles with the plasma membrane. ...

Recommended for you

Implantable islet cells come with their own oxygen supply

April 25, 2018
Since the 1960s, researchers have been interested in the possibility of treating type 1 diabetes by transplanting islet cells—the pancreatic cells that are responsible for producing insulin when blood glucose concentration ...

Study shows drug effectiveness in reducing glucocorticoid-induced bone loss

April 25, 2018
About one in every 100 people in the world takes glucocorticoids long term to treat immune-mediated diseases. However, glucocorticoids, such as prednisone, have a side effect—they induce the bone loss called osteoporosis, ...

Bariatric surgery successes lead to type 2 diabetes treatment

April 24, 2018
Bariatric surgery has long yielded almost immediate health benefits for patients with type 2 diabetes, and new findings on the reasons for remission may be the key to developing drug alternatives to surgery.

Hacking human 'drug trafficking' network could make diabetes treatments more effective

April 23, 2018
Making tiny changes to existing diabetes treatments can alter how they interact with cells, and potentially make the medicines more effective.

Vitamin D deficiency linked to greater risk of diabetes

April 19, 2018
An epidemiological study conducted by researchers at University of California San Diego School of Medicine and Seoul National University suggests that persons deficient in vitamin D may be at much greater risk of developing ...

One class of drug used to treat type 2 diabetes may not reduce the risk of death when compared with placebo

April 17, 2018
One class of drug used to treat type 2 diabetes may not reduce the risk of death when compared with placebo, suggests new findings.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.