NSAIDs, genetics and miscarriage

September 21, 2017 by Leigh Macmillan, Vanderbilt University
Credit: CC0 Public Domain

NSAIDs – anti-inflammatory drugs including aspirin and ibuprofen – affect signaling pathways important in achieving and maintaining pregnancy. Studies of their impact on miscarriage risk, however, have produced mixed results.

Digna Velez Edwards, Ph.D., and colleagues evaluated in NSAID metabolism and related pathways and miscarriage risk in a group of 600 European-American women enrolled in the Right from the Start prospective cohort.

The researchers identified an association between a variant in the prostacyclin synthase gene, PGIS, and miscarriage risk that was modified by NSAID use during . Among women with the PGIS variant, NSAID users were protected from miscarriage and non-NSAID users were at increased risk. The variant was also associated with increased levels of a pro-inflammatory prostaglandin.

The findings, published in Scientific Reports, suggest the potential for using genetic information to guide interventions that prevent adverse pregnancy outcomes. If verified, the results support NSAID treatment in women with the PGIS variant to reduce risk of miscarriage.

Explore further: Anti-inflammatory drugs taken in early pregnancy more than double risk of miscarriage

More information: Digna R. Velez Edwards et al. Nonsteroidal Anti-inflammatory Drug Interaction with Prostacyclin Synthase Protects from Miscarriage, Scientific Reports (2017). DOI: 10.1038/s41598-017-10150-2

Related Stories

Anti-inflammatory drugs taken in early pregnancy more than double risk of miscarriage

September 6, 2011
The risk of miscarriage is 2.4 times greater for women who took any type and dosage of nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) in early pregnancy, according to a study in CMAJ (Canadian Medical Association ...

History of stress increases miscarriage risk, says new review

August 17, 2017
A history of exposure to psychological stress can increase the risk of miscarriage by upto 42 per cent, according to a new review.

Researchers determine the best strategy for preventing ulcers when taking NSAIDs

May 13, 2016
Non-steroidal anti-inflammatory drugs (NSAIDs)—including ibuprofen, diclofenac, naproxen and others—are commonly used pain medications that are generally safe but may increase the risk of developing stomach and intestinal ...

NSAIDs do not increase risk of miscarriages, study reports

February 3, 2014
Women who take nonsteroidal anti-inflammatory drugs (NSAIDs) during pregnancy are not at increased risk of miscarriages, confirms a new study published in CMAJ (Canadian Medical Association Journal).

Study disputes link between uterine fibroids and miscarriage risk

June 7, 2017
A 10-year study, led by Vanderbilt University Medical Center professor of Obstetrics and Gynecology Katherine Hartmann, M.D., Ph.D., disrupts conventional wisdom that uterine fibroids cause miscarriages.

Possible miscarriage gene found: study

October 19, 2016
Scientists said Wednesday they had linked mutations in a specific gene with an increased risk of recurrent miscarriages, offering hopes of better diagnosis and treatment for affected women.

Recommended for you

Undiagnosed STIs can increase negative PMS symptoms

September 17, 2018
Women that have undiagnosed sexually transmitted infections may be at greater risk of experiencing negative premenstrual symptoms (PMS), according to new Oxford University research.

High dose folic acid does not prevent pre-eclampsia in high risk women

September 13, 2018
Taking high dose folic acid supplements in later pregnancy (beyond the first trimester) does not prevent pre-eclampsia in women at high risk for this condition, finds a randomised controlled trial published by The BMJ today.

Study finds air purifiers may benefit fetal growth

September 12, 2018
A new study led by SFU health sciences researchers Prabjit Barn and Ryan Allen reveals fetal growth may improve if pregnant women use portable air purifiers inside their homes.

Delayed childbearing is a growing source of multiple births, study shows

September 12, 2018
Starting in the 1980s, the number of multiple births—twins, triplets, quadruplets and quintuplets—steadily increased from about 20 sets per 1,000 live births to almost 35 sets per 1,000 live births in the 2010s.

Transforming pregnancy research with a smartphone app

September 5, 2018
For years, pregnant women have been underrepresented in biomedical research. Current treatments, interventions and guidelines do a poor job of taking into consideration the diverse characteristics of all pregnant women.

For women undergoing IVF, is fresh or frozen embryo transfer best?

August 21, 2018
The world's first baby born via in-vitro fertilization turned 40 years old this summer. Still, after four decades, IVF is a relatively new field with ongoing debate on how to get the best results for families who have placed ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.