NSAIDs, genetics and miscarriage

September 21, 2017 by Leigh Macmillan
Credit: CC0 Public Domain

NSAIDs – anti-inflammatory drugs including aspirin and ibuprofen – affect signaling pathways important in achieving and maintaining pregnancy. Studies of their impact on miscarriage risk, however, have produced mixed results.

Digna Velez Edwards, Ph.D., and colleagues evaluated in NSAID metabolism and related pathways and miscarriage risk in a group of 600 European-American women enrolled in the Right from the Start prospective cohort.

The researchers identified an association between a variant in the prostacyclin synthase gene, PGIS, and miscarriage risk that was modified by NSAID use during . Among women with the PGIS variant, NSAID users were protected from miscarriage and non-NSAID users were at increased risk. The variant was also associated with increased levels of a pro-inflammatory prostaglandin.

The findings, published in Scientific Reports, suggest the potential for using genetic information to guide interventions that prevent adverse pregnancy outcomes. If verified, the results support NSAID treatment in women with the PGIS variant to reduce risk of miscarriage.

Explore further: Anti-inflammatory drugs taken in early pregnancy more than double risk of miscarriage

More information: Digna R. Velez Edwards et al. Nonsteroidal Anti-inflammatory Drug Interaction with Prostacyclin Synthase Protects from Miscarriage, Scientific Reports (2017). DOI: 10.1038/s41598-017-10150-2

Related Stories

Anti-inflammatory drugs taken in early pregnancy more than double risk of miscarriage

September 6, 2011
The risk of miscarriage is 2.4 times greater for women who took any type and dosage of nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) in early pregnancy, according to a study in CMAJ (Canadian Medical Association ...

History of stress increases miscarriage risk, says new review

August 17, 2017
A history of exposure to psychological stress can increase the risk of miscarriage by upto 42 per cent, according to a new review.

Researchers determine the best strategy for preventing ulcers when taking NSAIDs

May 13, 2016
Non-steroidal anti-inflammatory drugs (NSAIDs)—including ibuprofen, diclofenac, naproxen and others—are commonly used pain medications that are generally safe but may increase the risk of developing stomach and intestinal ...

NSAIDs do not increase risk of miscarriages, study reports

February 3, 2014
Women who take nonsteroidal anti-inflammatory drugs (NSAIDs) during pregnancy are not at increased risk of miscarriages, confirms a new study published in CMAJ (Canadian Medical Association Journal).

Study disputes link between uterine fibroids and miscarriage risk

June 7, 2017
A 10-year study, led by Vanderbilt University Medical Center professor of Obstetrics and Gynecology Katherine Hartmann, M.D., Ph.D., disrupts conventional wisdom that uterine fibroids cause miscarriages.

Possible miscarriage gene found: study

October 19, 2016
Scientists said Wednesday they had linked mutations in a specific gene with an increased risk of recurrent miscarriages, offering hopes of better diagnosis and treatment for affected women.

Recommended for you

First time mums with an epidural who lie down more likely to have a normal birth

October 18, 2017
Adopting a lying down position rather than being upright in the later stages of labour for first-time mothers who have had a low dose epidural leads to a higher chance of them delivering their baby without any medical intervention, ...

Mice delivered by C-section gain more weight than those delivered naturally

October 11, 2017
Mice born by Caesarian section gained on average 33 percent more weight in the 15 weeks after weaning than mice born vaginally, with females gaining 70 percent more weight.

Study shows epidurals don't slow labor

October 10, 2017
Epidural analgesia - a mix of anesthetics and narcotics delivered by catheter placed close to the nerves of the spine - is the most effective method of labor pain relief. In widespread use since the 1970s, epidurals have ...

Progesterone does not prevent preterm birth or complications, says study

October 3, 2017
An increasingly popular hormonal "treatment" for pregnant women with a history of preterm birth does not work, a major new international study shows.

Study questions practice of placenta eating by new moms

September 29, 2017
(HealthDay)—You may have heard that some new mothers choose to eat their own placenta after childbirth. But there's no indication the trendy practice offers any health benefits, and some evidence it could prove dangerous, ...

Hope for couples suffering IVF miscarriage

September 20, 2017
Women who miscarry during their first full round of IVF are more likely to have a baby after further treatment than women who don't get pregnant at all.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.