Researchers identify genetic drivers of most common form of lymphoma

Lymphoma is the most common blood cancer, but the diagnosis belies a wildly diverse and little understood genetic foundation for the disease that hampers successful treatment.

An international research effort led by Duke Cancer Institute scientists has been working to better understand the of the most prevalent form of this cancer—diffuse large B cell lymphoma - and how those genes might play a role in patients' responses to therapies.

The researchers analyzed tumor samples from 1,001 patients who had been diagnosed with diffuse large B over the past decade. These patients had been treated at 12 institutions around the world.

Using whole exome sequencing, the researchers pinpointed 150 genetic drivers of the disease, many newly identified. The team then tested to see if there were any correlations between the genes and how well patients had responded to standard therapies. The team applied a genome editing technique known as CRISPR to knock out each of thel 20,000 genes in to identify those that are critical for to grow. By assessing the genetic, CRISPR and clinical results, the researchers found several critical genetic links that could help guide treatments.

These findings published online Oct. 5 in the journal Cell.

"This work provides a comprehensive road map in terms of research and clinical priorities," said Sandeep Davé, M.D., professor of medicine at Duke. "We have very good data now to pursue new and existing therapies that might target the genetic mutations we identified. Additionally, this data could also be used to develop genetic markers that steer patients to therapies that would be most effective."


Explore further

Genome sequencing of Burkitt Lymphoma reveals unique mutation

Journal information: Cell

Citation: Researchers identify genetic drivers of most common form of lymphoma (2017, October 5) retrieved 22 October 2019 from https://medicalxpress.com/news/2017-10-genetic-drivers-common-lymphoma.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
0 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more