Late gadolinium enhancement linked to prognosis in myocarditis

October 13, 2017

(HealthDay)—For patients with acute myocarditis (AM) with preserved left ventricular ejection fraction (LVEF) and for patients with suspected myocarditis, late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR) is associated with worse prognosis, according to two studies published online Oct. 9 in the Journal of the American College of Cardiology.

Giovanni Donato Aquaro, M.D., from the Gabriele Monasterio Foundation in Italy, and colleagues assessed CMR results from 374 patients with AM and preserved LVEF. The researchers found that 41 percent of patients had LGE that involved the subepicardial layer inferior and lateral wall, 36 percent had LGE that involved the midwall layer of the anteroseptal wall (AS group), and 16 percent had LGE in other segments; 26 patients had no LGE. Compared with other groups, the AS group had a greater extent of LGE and higher LV end-diastolic volume index but lower levels of inflammatory markers. The AS group had worse prognosis than other groups. AS LGE was the best independent CMR predictor of the combined end point of cardiac death, appropriate implantable cardioverter-defibrillator firing, resuscitated cardiac arrest, and hospitalization for heart failure (odds ratio, 2.73).

Christoph Gräni, M.D., from Harvard Medical School in Boston, and colleagues followed 670 patients with suspected myocarditis who underwent CMR. The researchers found that 98 patients experienced a major adverse cardiovascular event (MACE) at a median follow-up of 4.7 years. Overall, 44 percent of patients showed LGE presence, which correlated with increased risk of MACE (hazard ratio, 2.22). LGE presence maintained a significant correlation with MACE in the multivariable model (hazard ratio, 1.72).

"CMR tissue characterization provides effective risk stratification in with suspected myocarditis," Gräni and colleagues write.

One author from the Aquaro study and two authors from the Gräni study disclosed financial ties to the pharmaceutical or medical device industry.

Explore further: Left ventricular mass index predicts all-cause mortality

More information: Abstract—Aquaro
Full Text (subscription or payment may be required)
Abstract—Gräni
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

Left ventricular mass index predicts all-cause mortality

July 26, 2017
(HealthDay)—Left ventricular (LV) mass index independently predicts all-cause mortality and the need for revascularization in patients undergoing invasive coronary angiography, according to a study published online July ...

Adding defibrillator to CRT no benefit in dilated cardiomyopathy

April 3, 2017
(HealthDay)—For patients with heart failure with indications for cardiac resynchronization therapy (CRT), those with ischemic cardiomyopathy (ICM), but not those with nonischemic dilated cardiomyopathy (DCM), benefit from ...

Revascularization cuts mortality, MACE in coronary CTO

February 21, 2015
(HealthDay)—For patients with coronary chronic total occlusion (CTO) and well-developed collateral circulation, revascularization is associated with reduced risk of cardiac mortality and major adverse cardiac events (MACE), ...

LVEF improvement for many with primary prevention ICDs

July 30, 2015
(HealthDay)—Forty percent of patients with primary prevention implantable cardioverter-defibrillators (ICDs) experience improvement in left ventricular ejection fraction (LVEF), according to a study published in the Aug. ...

Scarring of heart muscle linked with increased risk of death in patients with type of cardiomyopathy

March 5, 2013
Detection of midwall fibrosis (the presence of scar tissue in the middle of the heart muscle wall) via magnetic resonance imaging among patients with nonischemic dilated cardiomyopathy (a condition affecting the heart muscle) ...

Mortality up with impaired LV global longitudinal strain in CKD

July 13, 2017
(HealthDay)—Severely impaired left ventricular (LV) global longitudinal strain (GLS) is associated with worse prognosis in predialysis and dialysis patients, according to a study published in the Aug. 1 issue of The American ...

Recommended for you

No sweat required: Team finds hypertension treatment that mimics effect of exercise

October 16, 2018
Couch potatoes rejoice—there might be a way to get the blood pressure lowering benefits of exercise in pill form.

New model suggests cuffless, non-invasive blood pressure monitoring possible using pulse waves

October 16, 2018
A large team of researchers from several institutions in China and the U.S. has developed a model that suggests it should be possible to create a cuffless, non-invasive blood pressure monitor based on measuring pulse waves. ...

Why heart contractions are weaker in those with hypertrophic cardiomyopathy

October 16, 2018
When a young athlete suddenly dies of a heart attack, chances are high that they suffer from familial hypertrophic cardiomyopathy (HCM). Itis the most common genetic heart disease in the US and affects an estimated 1 in 500 ...

Novel genetic study sheds new light on risk of heart attack

October 12, 2018
Loss of a protein that regulates mitochondrial function can greatly increase the risk of myocardial infarction (heart attack), Vanderbilt scientists reported Oct. 3 in the journal eLife.

Researchers say ritual for orthodox Jewish men may offer heart benefits

October 11, 2018
A pilot study led by researchers at the University of Cincinnati (UC) College of Medicine suggests Jewish men who practice wearing tefillin, which involves the tight wrapping of an arm with leather banding as part of daily ...

Markers of dairy fat consumption linked to lower risk of type two diabetes

October 10, 2018
Higher levels of biomarkers of dairy fat consumption are associated with a lower risk of developing type 2 diabetes, according to new research published today in PLOS Medicine. The study, in more than 60,000 adults, was undertaken ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.