Risk of CIN3 drops with negative HPV, cytology co-tests

November 28, 2017

(HealthDay)—The five-year risks of cervical intraepithelial neoplasia grade 3 (CIN3), adenocarcinoma in situ, and cervical cancer (≥CIN3) decrease after each successive negative human papillomavirus (HPV) and cytology co-testing, according to a study published online Nov. 27 in the Annals of Internal Medicine.

Philip E. Castle, Ph.D., M.P.H., from the Albert Einstein College of Medicine in Bronx, N.Y., and colleagues conducted an observational cohort study involving 990,013 women who had one or more co-tests from 2003 to 2014. The authors examined the three- and five-year cumulative detection of ≥CIN3.

The researchers observed a decrease in five-year ≥CIN3 risks after each successive negative co-test screening round (0.098, 0.052, and 0.035 percent for first, second, and third co-test, respectively). Regardless of the cytology result, five-year ≥CIN3 risks for an HPV-negative co-test nearly matched the performance of a negative co-test for each successive round of screening (0.114, 0.061, and 0041 percent, respectively). For the cytology-negative co-test, ≥CIN3 risks also decreased with each successive round, regardless of the HPV result, but the three-year risks were as high as five-year risks after an HPV-negative co-test (0.199, 0.065, and 0.043 percent, respectively). After the second negative co-test, no interval cases were diagnosed.

"After one or more negative cervical co-tests (or HPV tests), longer intervals (every five years or more) might be feasible and safe," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Explore further: Low incidence of cervical cancer, CIN3+ for HPV-negative women

More information: Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

Low incidence of cervical cancer, CIN3+ for HPV-negative women

October 7, 2016
(HealthDay)—Human papillomavirus (HPV)-negative women have low long-term incidence of cervical cancer and cervical intraepithelial neoplasia (CIN) grade 3 or worse (CIN3+), which supports an extension of the cervical screening ...

Risk of noncervical anogenital cancer up with history of CIN2/3

July 6, 2016
(HealthDay)—Women with a history of cervical intraepithelial neoplasia (CIN)2 or CIN3 have increased risks of subsequent development of anal, vulvar, and vaginal cancers, according to a study published online June 29 in ...

HIV-seropositive CIN3+ patients have lower HPV16 prevalence

March 16, 2016
(HealthDay)—HIV-seropositive women with cervical intraepithelial neoplasia (CIN) grade ≥3 (CIN3+) are less likely to have human papillomavirus (HPV) 16, according to a study published in the March issue of the American ...

Screening for cervical abnormalities in women offered HPV vaccination

September 19, 2017
Human papillomavirus (HPV) testing detects a higher number of precancerous cervical lesions than cytology-based Pap smears in a female population including a proportion offered HPV vaccination, according to a new study published ...

HPV testing followed by smear could improve cervical screening

February 29, 2012
(Medical Xpress) -- Testing for the human papillomavirus (HPV) – a virus most women will encounter at some point in their lives – followed by a smear test if they are HPV positive, provides the most effective approach ...

Recommended for you

Three scientists share $500,000 prize for work on cancer therapy

August 15, 2018
Tumors once considered untreatable have disappeared and people previously given months to live are surviving for decades thanks to new therapies emerging from the work of three scientists chosen to receive a $500,000 medical ...

RUNX proteins act as regulators in DNA repair, study finds

August 15, 2018
A study by researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore has revealed that RUNX proteins are integral to efficient DNA repair via the Fanconi Anemia (FA) ...

Chemicals found in vegetables prevent colon cancer in mice

August 14, 2018
Chemicals produced by vegetables such as kale, cabbage and broccoli could help to maintain a healthy gut and prevent colon cancer, a new study from the Francis Crick Institute shows.

Researchers artificially generate immune cells integral to creating cancer vaccines

August 14, 2018
For the first time, Mount Sinai researchers have identified a way to make large numbers of immune cells that can help prevent cancer reoccurrence, according to a study published in August in Cell Reports.

Stress hormone is key factor in failure of immune system to prevent leukemia

August 14, 2018
The human stress hormone cortisol has been identified by scientists at the University of Kent as a key factor when the immune system fails to prevent leukemia taking hold.

Medically underserved women in the Southeast rarely receive BRCA tests

August 14, 2018
Medically underserved women in the Southeast diagnosed with breast cancer or ovarian cancer missed out on genetic testing that could have helped them and their relatives make important decisions about their health, according ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.