Study ends debate over best way to prevent acute kidney failure post angiogram

November 13, 2017, George Institute for Global Health

Treatments commonly used to prevent acute kidney failure and its complications arising from common angiography procedures make no difference to health outcomes, a major new study has found.

A team of international researchers studied the effectiveness of two common treatments used to prevent serious harm to patients undergoing angiography.

The worldwide study published in the New England Journal of Medicine investigated the effects of and -N-acetylcysteine and found that neither were any better than using saline alone. These treatments were thought to reduce the impact of the contrast agents used in angiography upon kidney function, having been studied and used for over 15 years.

Lead author Dr. Steven Weisbord, of the Veteran's Administration, said: "Both of these treatments are used in hospitals all over the world with the belief that they are helping patients. The scientific evidence to support such practice has been confusing, so the use of these treatments varies between hospitals and individual doctors.

Co-author Assoc Prof Martin Gallagher, of The George Institute for Global Health, added: "This definitive study has shown that these treatments are not helping people avoid nor the other poor outcomes that result from this complication. In addition, they are adding unnecessary complexity and cost."

Millions of these angiograms are performed around the world annually, with some 76,000 heart-related angiograms done in Australia every year. Patients who have a history of , heart failure or diabetes have a higher risk of these complications, which are associated with longer hospital stay, higher mortality and worsening of .

Dr Weisbord said: "Whilst these treatments do not appear to cause harm, our results suggest that patients should instead just be treated with saline which is both cheaper and more readily available."

Explore further: Diabetes may have important effects in patients with acute heart failure

Related Stories

Diabetes may have important effects in patients with acute heart failure

June 26, 2017
Researchers have found that patients with acute heart failure and diabetes, compared with those without diabetes, have distinct markers related to inflammation, cardiovascular function, and kidney health.

Kidney problems may prevent heart attack patients from receiving life-saving care

June 17, 2014
Heart attack patients with kidney problems may not be getting the full treatment they need, according to a new study led by King's College London. The study found that patients admitted to hospital with chest pains and poorly ...

Prophylactic sodium bicarbonate infusion and acute kidney injury after open heart surgery

April 16, 2013
Contrary to the positive findings of a previous pilot study, administration of a sodium bicarbonate-based infusion to induce urinary alkalinization during and after surgery does not reduce the incidence of acute kidney injury ...

Vitamin E may decrease the risk of acute kidney injury after coronary catheterization

March 15, 2017
Acute kidney injury is quite a common adverse effect that associates with coronary angiography and percutaneous coronary interventions. Vitamin E may decrease the risk of acute kidney injury by up to 62% according to a meta-analysis ...

ASN: Severe acute kidney injury ups risk of 28-day mortality

November 21, 2016
(HealthDay)—Acute kidney injury is associated with increased risk of 28-day mortality among critically ill children and young adults, according to a study published online Nov. 18 in the New England Journal of Medicine. ...

Non-contrast MRA provides safe diagnostic alternative for patients with kidney disease

September 28, 2016
Patients with diabetes or renal failure are at high risk for deadly and debilitating vascular diseases, however, the most common imaging tool to evaluate the blood vessels uses a contrast agent that can further damage the ...

Recommended for you

RNA processing and antiviral immunity

December 14, 2018
The RIG-I like receptors (RLRs) are intracellular enzyme sentries that detect viral infection and initiate a first line of antiviral defense. The cellular molecules that activate RLRs in vivo are not clear.

Faster test for Ebola shows promising results in field trials

December 13, 2018
A team of researchers with members from the U.S., Senegal and Guinea, in cooperation with Becton, Dickinson and Company (BD), has developed a faster test for the Ebola virus than those currently in use. In their paper published ...

Drug targets for Ebola, Dengue, and Zika viruses found in lab study

December 13, 2018
No drugs are currently available to treat Ebola, Dengue, or Zika viruses, which infect millions of people every year and result in severe illness, birth defects, and even death. New research from the Gladstone Institutes ...

Urbanisation and air travel leading to growing risk of pandemic

December 13, 2018
Increased arrivals by air and urbanisation are the two main factors leading to a growing vulnerability to pandemics in our cities, a University of Sydney research team has found.

Researchers discover new interactions between Ebola virus and human proteins

December 13, 2018
Several new connections have been discovered between the proteins of the Ebola virus and human host cells, a finding that provides insight on ways to prevent the deadly Ebola virus from reproducing and could lead to novel ...

Faecal transplants, 'robotic guts' and the fight against deadly gut bugs

December 13, 2018
A simple compound found in our gut could help to stop dangerous bacteria behind severe, and sometimes fatal, hospital infections.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.