Disrupted sleep linked to increased amyloid-beta production
Brendan P. Lucey, M.D., from the Washington University School of Medicine in St. Louis, and colleagues examined whether sleep disruption increases soluble amyloid-β using indwelling lumbar catheters to serially sample cerebrospinal fluid while eight participants (aged 30 to 60 years) were sleep-deprived, treated with sodium oxybate, or allowed to sleep normally. Amyloid-β kinetics were measured by infusion with 13C6-leucine.
The researchers found that, compared with controls who were allowed to sleep normally, sleep deprivation correlated with increased overnight amyloid-β-38, amyloid-β-40, and amyloid-β42 levels (25 to 30 percent increases).
"These findings suggest that disrupted sleep increases Alzheimer's disease risk via increased amyloid-β production," the authors write.
Several authors disclosed financial ties to C2N Diagnostics, including receiving royalties for patents and technology.
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