DPP-4 inhibitor has dissociated effects on β-cell function
Wathik Al Salim, M.D., from Lund University in Sweden, and colleagues examined the effects of a single dose of sitagliptin on glucose-standardized insulin secretion and β-cell sensitivity after meal ingestion. Twelve healthy and 12 drug-naive subjects with well-controlled T2D received sitagliptin or placebo before a meal.
The researchers found that, compared with placebo, sitagliptin was correlated with increased standardized insulin secretion in healthy and T2D subjects without increasing β-cell glucose sensitivity. Increases in active glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) were also seen with sitagliptin, as were decreases in total GIP but not total GLP-1 levels.
"We conclude that a single dose of DPP-4 inhibition induces dissociated effects on different aspects of β-cell function and incretin hormones after meal ingestion in healthy subjects and in well-controlled T2D," the authors write.
Several authors disclosed financial ties to the pharmaceutical industry.
Full Text (subscription or payment may be required)
Copyright © 2017 HealthDay. All rights reserved.