Rituximab effective for lupus-associated cytopenia

Rituximab effective for lupus-associated cytopenia

(HealthDay)—Rituximab treatment seems effective for systemic lupus erythematosus (SLE)-associated immune cytopenias, with an overall initial response rate of 86 percent, according to a study published online Dec. 16 in the American Journal of Hematology.

Alexandra Serris, M.D., from the Université Paris-Est Créteil, and colleagues conducted a involving 71 patients aged ≥18 years with a definite diagnosis of SLE treated with specifically for SLE-associated immune cytopenia.

The researchers found that the median duration of SLE at the time of first rituximab administration was 6.1 years. The reason for using rituximab was , autoimmune hemolytic anemia, Evans syndrome, and pure red cell aplasia for 44, 16, 10, and one patient, respectively. Patients had a mean of 3.1±1.3 treatments before receiving rituximab, including corticosteroids and hydroxychloroquine (100 and 88.5 percent, respectively). The overall initial response rate to rituximab was 86 percent, with a complete response for 60.5 percent. Of the 61 initial responders, 24 relapsed; rituximab re-treatment was successful for 16 of 18. Three patients had severe infections after rituximab, with no fatal outcomes. There were no cases of rituximab-induced neutropenia.

"In conclusion, rituximab seems effective and relatively safe for treating SLE-associated immune cytopenias," the authors write.

Several authors disclosed financial ties to Roche.


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Citation: Rituximab effective for lupus-associated cytopenia (2017, December 27) retrieved 17 October 2019 from https://medicalxpress.com/news/2017-12-rituximab-effective-lupus-associated-cytopenia.html
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