CV exercise betters cardiac aging in sedentary middle-aged adults

January 9, 2018

(HealthDay)—Two years of high-intensity exercise training (ExT) is associated with improved maximal oxygen uptake and reduced cardiac stiffness in previously sedentary healthy middle-aged adults, according to a study published online Jan. 8 in Circulation.

Erin J. Howden, Ph.D., from the Texas Health Presbyterian Hospital in Dallas, and colleagues randomized 61 healthy, sedentary, middle-aged participants to two years of ExT or attention control (control); 53 participants completed the study. Left ventricular (LV) end-diastolic pressure-volume relationships (EDPVR) and Frank-Starling curves were defined using right heart catheterization and three-dimensional echocardiography. Changes in fitness were quantified using maximal oxygen uptake.

The researchers found that there was 88 ± 11 percent adherence to prescribed exercise sessions. Maximal uptake increased by 18 percent (ExT: 34.4 ± 6.4; : 28.7 ± 5.4; P < 0.001), while there was a reduction in LV stiffness in the ExT group (right/downward shift in the EDPVR: ExT: pre- to post-stiffness constant: 0.072 ± 0.037 to 0.051 ± 0.0268; P < 0.0018) but not in controls (pre- to post-stiffness constant: 0.0635 ± 0.026 to 0.062 ± 0.031; P = 0.83). LV end-diastolic volume was increased by exercise (P < 0.001), while there was no change in pulmonary capillary wedge pressure, resulting in greater stroke volume for any given filling pressure (P = 0.007).

"In previously sedentary healthy middle-age adults, two-years of training improved and decreased cardiac stiffness," the authors write.

Explore further: Middle-aged couch potatoes may reverse heart effects of a sedentary life with exercise training

More information: Abstract/Full Text (subscription or payment may be required)

Related Stories

Middle-aged couch potatoes may reverse heart effects of a sedentary life with exercise training

January 8, 2018
Middle-aged couch potatoes may reduce or reverse the risk of heart failure associated with years of sitting if they participate in two years of regular aerobic exercise training, according to a new study in the American Heart ...

Amount or intensity? Study examines potential benefits of exercise for patients with heart failure

December 6, 2017
Physical activity can benefit patients with heart failure with preserved ejection fraction, a common condition with no pharmacological treatment, but no clear recommendations exist on the optimal amount or intensity of physical ...

Exercise training improves left ventricular function in T1DM

July 24, 2017
(HealthDay)—For adolescents with type 1 diabetes, a 20-week exercise training intervention is associated with improved aerobic capacity and stroke volume, according to a study published online July 18 in Diabetes Care.

Proper exercise can reverse damage from heart aging

January 8, 2018
Exercise can reverse damage to sedentary, aging hearts and help prevent risk of future heart failure - if it's enough exercise, and if it's begun in time, according to a new study by cardiologists at UT Southwestern and Texas ...

Pioglitazone improves left ventricular diastolic function

September 29, 2017
(HealthDay)—Pioglitazone improves whole-body and myocardial insulin sensitivity, left ventricular (LV) diastolic function, and systolic function in patients with type 2 diabetes, according to a small study published online ...

Cardiac patients benefit from home-based high intensity training

December 5, 2013
Rapid rehabilitation is a must after a heart attack or other cardiovascular event. Different forms of exercise as a part of rehabilitation have been examined by researchers, including high-intensity interval training (85-95 ...

Recommended for you

Infections could trigger stroke in pregnant women during hospital delivery

April 20, 2018
Pregnant women who have an infection when they enter the hospital for delivery might be at higher risk of having a stroke during their stay, according to new research.

Compound improves stroke outcome by reducing lingering inflammation

April 20, 2018
An experimental compound appears to improve stroke outcome by reducing the destructive inflammation that can continue months after a stroke, scientists report.

Novel antioxidant makes old blood vessels seem young again

April 19, 2018
Older adults who take a novel antioxidant that specifically targets cellular powerhouses, or mitochondria, see age-related vascular changes reverse by the equivalent of 15 to 20 years within six weeks, according to new University ...

Changing how blood pressure is measured will save lives

April 19, 2018
Traditional methods of testing for high-blood pressure are no longer adequate and risk missing vital health signs, which can lead to premature death, a study co-led by UCL has found.

Eyes of adolescents could reveal risk of cardiovascular disease

April 19, 2018
New research has found that poorer well-being or 'health-related quality of life' (HRQoL) in adolescence could be an indicator of future cardiovascular disease risk.

Obesity linked with higher chance of developing rapid, irregular heart rate

April 18, 2018
People with obesity are more likely to develop a rapid and irregular heart rate, called atrial fibrillation, which can lead to stroke, heart failure and other complications, according to Penn State researchers.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.