Neurodevelopment not impacted by glucocorticoids in preemies

January 11, 2018

(HealthDay)—Use of inhaled glucocorticoids in extremely preterm infants for the prevention of bronchopulmonary dysplasia does not lead to a higher rate of neurodevelopmental disability at 2 years, according to a study published in the Jan. 11 issue of the New England Journal of Medicine.

Dirk Bassler, M.D., from University of Zurich, and colleagues randomly assigned 863 infants (gestational age, 23 weeks 0 days to 27 weeks 6 days) to receive early (within 24 hours after birth) inhaled budesonide or placebo. A long-term composite outcome of neurodevelopmental disability among survivors included , cognitive delay (a Mental Development Index score of <85 on the Bayley Scales of Infant Development, Second Edition), deafness, or blindness at a corrected age of 18 to 22 months.

Based on follow-up data from 629 infants, the researchers found that 148 of 308 infants assigned to budesonide had neurodevelopmental disability versus 165 of 321 infants assigned to placebo (relative risk, adjusted for , 0.93; 95 percent confidence interval, 0.80 to 1.09; P = 0.40). For individual components of the composite outcome there was similarly no significant differences. However, there were more deaths among infants randomized to budesonide, compared to those given placebo (relative risk, 1.37; 95 percent confidence interval, 1.01 to 1.86; P = 0.04).

"We found no effect of budesonide on the risk of neurodevelopmental disability among surviving extremely preterm infants at 18 to 22 months of age," the authors write. "However, the mortality rate was higher in the budesonide group."

The research was funded by Chiesi Farmaceutici, which provided the study drugs free of charge.

Explore further: Budesonide may be beneficial in extremely preterm infants

More information: Abstract/Full Text (subscription or payment may be required)

Related Stories

Budesonide may be beneficial in extremely preterm infants

October 15, 2015
(HealthDay)—For extremely premature infants, early inhaled budesonide is associated with reduced incidence of bronchopulmonary dysplasia but may be linked to increased mortality, according to a study published online Oct. ...

EPO in very preterm infants does not improve neurodevelopmental outcomes at two years

May 17, 2016
In a study appearing in the May 17 issue of JAMA, Giancarlo Natalucci, M.D., of the University of Zurich, Switzerland, and colleagues randomly assigned 448 preterm infants born between 26 weeks 0 days' and 31 weeks 6 days' ...

Administration of steroid to extremely preterm infants not associated with adverse effects on neurod

April 4, 2017
The administration of low-dose hydrocortisone to extremely preterm infants was not associated with any adverse effects on neurodevelopmental outcomes at 2 years of age, according to a study published by JAMA.

Enteral DHA doesn't cut preemie bronchopulmonary dysplasia risk

March 30, 2017
(HealthDay)—Enteral docosahexaenoic acid (DHA) supplementation does not reduce the risk of bronchopulmonary dysplasia for infants born before 29 weeks of gestation, according to a study published in the March 30 issue of ...

Study examines neurodevelopmental outcomes for children born extremely preterm

April 30, 2013
Fredrik Serenius, M.D., Ph.D., of Uppsala University, Uppsala, Sweden, and colleagues conducted a study to assess neurological and developmental outcome in extremely preterm (less than 27 gestational weeks) children at 2.5 ...

Hypoxia challenge test can ID fitness to fly in neonates

February 16, 2016
(HealthDay)—Many infants with bronchopulmonary dysplasia (BPD) fail hypoxia challenge testing (HCT) and cannot be deemed fit to fly, according to a study published online Feb. 15 in Pediatrics.

Recommended for you

Digital media use linked to behavioral problems in kids

July 17, 2018
Are children who spend lots of time using digital devices prone to psychiatric problems? A team of USC scientists says yes in a new study that appears today in the Journal of the American Medical Association.

Childhood abuse linked to greater risk of endometriosis, study finds

July 17, 2018
Endometriosis, a painful condition that affects one in 10 reproductive-age women in the U.S., has been linked to childhood physical and sexual abuse, according to findings published today in the journal Human Reproduction.

Opioids given too easily to children: study

July 16, 2018
(HealthDay)—Many children are prescribed powerful opioid painkillers they don't really need, putting them and those around them at risk, a new study shows.

Self-control and obesity: Gender matters in children

July 16, 2018
A toddler's self-regulation—the ability to change behavior in different social situations—may predict whether he or she will be obese come kindergarten, but the connection appears to be much different for girls than for ...

Footwear habits influence child and adolescent motor skill development

July 11, 2018
New research finds that children and adolescents who spend most of their time barefoot develop motor skills differently from those who habitually wear shoes. Published in Frontiers in Pediatrics, this is the first study to ...

Parents who had severe trauma, stresses in childhood more likely to have kids with behavioral health problems

July 9, 2018
A new study finds that severe childhood trauma and stresses early in parents' lives are linked to higher rates of behavioral health problems in their own children.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.