Choose Omega-3s from fish over flax for cancer prevention, study finds

January 26, 2018, University of Guelph
Choose Omega-3s from fish over flax for cancer prevention, study finds
Credit: University of Guelph

Omega-3s from fish pack a stronger punch than flaxseed and other oils when it comes to cancer prevention, according to a first-ever University of Guelph study.

Prof. David Ma has discovered that marine-based omega-3s are eight times more effective at inhibiting tumour development and growth.

"This study is the first to compare the cancer-fighting potency of plant- versus marine-derived omega-3s on breast tumour development," said the professor in the Department of Human Health and Nutritional Sciences. "There is evidence that both omega-3s from plants and marine sources are protective against cancer and we wanted to determine which form is more effective."

There are three types of : a-linolenic (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). ALA is plant-based and found in such edible seeds as flaxseed and in oils, such as soy, canola and hemp oil. EPA and DHA are found in marine life, such as fish, algae and phytoplankton.

Published in the Journal of Nutritional Biochemistry, the study involved feeding the different types of omega-3s to mice with a highly aggressive form of human called HER-2. HER-2 affects 25per cent of women and has a poor prognosis.

Ma exposed the mice to either the plant-based or the marine-based omega-3s, beginning in utero.

"The mice were exposed to the different omega-3s even before tumours developed, which allowed us to compare how effective the fatty acids are at prevention," said Ma. "It's known that EPA and DHA can inhibit breast tumour growth, but no one has looked directly at how effective these omega-3s are compared to ALA."

Ma found overall exposure to marine-based omega-3s reduced the size of the tumours by 60 to 70 per cent and the number of tumours by 30 per cent.

However, higher doses of the plant-based fatty acid were required to deliver the same impact as the marine-based omega-3s.

Omega-3s prevent and fight cancer by turning on genes associated with the immune system and blocking tumour growth pathways, said Ma.

"It seems EPA and DHA are more effective at this. In North America, we don't get enough omega-3s from seafood, so there lies an opportunity to improve our diet and help prevent the risk of breast cancer."

Based on the doses given in the study, Ma said humans should consume two to three servings of fish a week to have the same effect.

Besides certain foods containing EPA and DHA, supplements and functional foods, such as omega-3 eggs or DHA milk, can offer similar effects, he added.

The next step is to investigate the effects of omega-3s on other forms of breast cancer.

"Seeing the significant benefits omega-3s can have in combatting a highly aggressive form of breast cancer means omega-3s will likely be beneficial for other types of ."

Explore further: Study finds new link between omega fatty acids and bowel cancer

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deksman2
not rated yet Jan 28, 2018
Microalgae contain high quantities of both EPA and DHA...
Fish for example get their Omega 3's from algae.

Cut out the middle-man (aka fish that feel pain) and just go directly for the source instead.

Breast cancer is commonly associated with high consumption of animal products in the first place (which includes fish).
There's also the issue of waste swimming in the oceans and it was stated that by 2050, we'll have more trash than fish in the oceans.
Plus, there's the additional problem of over-fishing.

This kind of practice is not sustainable... nor is it healthy for Humans.

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