Opioids plus acetaminophen, ketorolac cost-effective post-Sx

Opioids plus acetaminophen, ketorolac cost-effective post-sx

(HealthDay)—Intravenous acetaminophen with or without ketorolac is associated with reduced opioid consumption and cost of care after scoliosis surgery in adolescents, compared with opioids alone, according to a study published online Jan. 29 in Pediatric Anesthesia.

Vidya Chidambaran, M.D., from the Cincinnati Children's Hospital Medical Center, and colleagues modeled the cost-effectiveness of adding acetaminophen or acetaminophen plus ketorolac to opioids for postoperative outcomes in children having . Out of 106 post-surgical children, 36 received only opioids, 26 received intravenous acetaminophen, and 44 received acetaminophen plus ketorolac as analgesia adjuncts.

The researchers found that subjects in the intravenous acetaminophen plus ketorolac strategy consumed fewer opioids (difference in mean morphine consumption on days one and two post-surgery, −0.44 mg/kg), tolerated meals earlier (relative risk [RR], 0.25), and had less constipation (RR, 0.226) compared to patients receiving opioids only. In base-case analysis, use of opioids alone was both most costly and least effective, while opioids plus intravenous acetaminophen was intermediate in both cost and effectiveness, and opioids plus intravenous acetaminophen and ketorolac was the least expensive and most effective strategy. Adding intravenous acetaminophen with or without ketorolac to an -only strategy resulted in savings of $510 to $947 per patient undergoing spine surgery and also resulted in decreased opioid side effects.

"Generalizing our results to the 38,000 spine fusions performed annually in the United States for patients with , using pain adjuncts IV and could result in substantial cost savings," the authors write.


Explore further

ASA: opioid-free anesthesia feasible for surgical procedures

More information: Abstract
Full Text (subscription or payment may be required)

Copyright © 2018 HealthDay. All rights reserved.

Citation: Opioids plus acetaminophen, ketorolac cost-effective post-Sx (2018, February 15) retrieved 21 July 2019 from https://medicalxpress.com/news/2018-02-opioids-acetaminophen-ketorolac-cost-effective-post-sx.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
2 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more