Children with autism and their younger siblings less likely to be fully vaccinated

March 26, 2018, Kaiser Permanente

Children with autism and their younger siblings are significantly less likely to be fully vaccinated than the general population, according to new Kaiser Permanente research published today in JAMA Pediatrics.

"In this large and comprehensive study, we found that after received an diagnosis, the rates of vaccination were significantly lower when compared with children of the same age who did not have an ," said lead author Ousseny Zerbo, PhD, postdoctoral fellow with the Kaiser Permanente Northern California Division of Research.

The retrospective matched cohort study, "Vaccination Patterns in Children After Autism Spectrum Disorder Diagnosis and in Their Younger Siblings," included more than 3,700 children with autism spectrum disorders diagnosed by 5 years of age, and nearly 500,000 children without ASD born between Jan. 1, 1995 and Sept. 30, 2010; and their respective , born between Jan. 1, 1997 and Sept. 30, 2014.

The researchers reviewed whether the children received vaccines recommended by the Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices. The data were drawn from six sites participating in the CDC's Vaccine Safety Datalink: Kaiser Permanente locations in California, Colorado, Oregon and Washington, and Marshfield Clinic in Wisconsin.

"There were large disparities in vaccination rates between children with and without autism spectrum disorders, as well as between their siblings, across all age groups and after adjusting for important confounding factors," said senior author Nicola Klein, MD, PhD, director of the Kaiser Permanente Vaccine Study Center.

For example, among children aged 7 years or older, 94 percent of those without an ASD received all vaccines recommended between 4 and 6 years of age, compared with 82 percent of those with an ASD; and for the measles, mumps, rubella (or MMR) vaccine, 96 percent of those without an ASD were vaccinated, compared with 84 percent of those with an ASD.

In addition, the proportion of children who were fully vaccinated with the recommended vaccines was also lower among younger siblings of children with ASD compared with younger siblings of children without ASD. For example, for vaccines recommended between one and 11 months, 73 percent of younger siblings of children with ASD were fully vaccinated compared to 85 percent of younger siblings of children without ASD.

"Numerous scientific studies have reported no association between childhood vaccination and the incidence of autism spectrum disorders," said co-author Frank DeStefano, MD, MPH, Immunization Safety Office, Centers for Disease Control and Prevention. "Nonetheless, this new study suggests that many children with autism and their younger siblings are not being fully vaccinated.

"We need to better understand how to improve vaccination levels in children with and their siblings, so they can be fully protected against -preventable diseases."

Explore further: Autism risk in younger children increases if they have older sibling with disorder

More information: JAMA Pediatrics (2018). jamanetwork.com/journals/jamap … pediatrics.2018.0082

Related Stories

Autism risk in younger children increases if they have older sibling with disorder

August 5, 2016
A new Kaiser Permanente study found that the risk of younger siblings developing an autism spectrum disorder is 14 times higher if an older sibling has ASD. The study, which was published today in Journal of Developmental ...

Another study finds no link between vaccine, autism

April 21, 2015
Yet another scientific study has found no link between autism and the vaccine against measles, mumps and rubella (MMR), according to US research published on Tuesday.

Infants who receive multiple vaccinations not at increased risk for infection

March 6, 2018
Infants who receive multiple vaccines as part of the routine vaccination schedule are unlikely to be more susceptible to other infections not targeted by those vaccines in the two years following vaccination, according to ...

Study finds children exposed to complications at birth at risk of autism

January 31, 2017
Children who were exposed to complications shortly before or during birth, including birth asphyxia and preeclampsia, were more likely to develop autism spectrum disorder, according to a Kaiser Permanente study published ...

Largest study to date reveals gender-specific risk of autism occurrence among siblings

September 25, 2017
Having one child with autism is a well-known risk factor for having another one with the same disorder, but whether and how a sibling's gender influences this risk has remained largely unknown.

Having an older sibling poses risk of serious flu for babies and toddlers

September 28, 2017
Children under two years are more likely to be admitted to hospital with influenza if they have an older sister or brother, according to research published today (Thursday) in the European Respiratory Journal.

Recommended for you

Fatty acids can slow down an overheated immune system

September 21, 2018
Sometimes, the immune system mistakenly attacks the body's healthy tissue by responding to infections that do not exist. This causes chronic inflammation and leads to diseases including lupus (SLE), and this is what happens ...

Patient-centered visual aid helps physicians discuss risks, treatments with parents

September 21, 2018
A series of illustrations and charts designed as decision aids for parents of children with minor head injuries helped them communicate with emergency medicine physicians and make informed decisions about their child's care, ...

Study shows surprise low-level ozone impact on asthma patients

September 21, 2018
A new study led by UNC School of Medicine researchers indicates that ozone has a greater impact on asthma patients than previously thought. The study, published in the Journal of Allergy and Clinical Immunology, recruited ...

Fish-rich diets may boost babies' brain development

September 20, 2018
Women could enhance the development of their unborn child's eyesight and brain function by regularly eating fatty fish during pregnancy. This is the suggestion from a small-scale study led by Kirsi Laitinen of the University ...

Understanding epilepsy in pediatric tumors

September 20, 2018
Pediatric brain tumors are characterized by frequent complications due to intractable epilepsy compared to adult brain tumors. However, the genetic cause of refractory epilepsy in pediatric brain cancer has not been elucidated ...

3-D-printed tracheal splints used in groundbreaking pediatric surgery

September 19, 2018
Children's Healthcare of Atlanta has performed Georgia's first-ever procedure to place 3-D-printed tracheal splints in a pediatric patient. A cross-functional team of Children's surgeons used three custom-made splints, which ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.