Drug helps mouse and monkey brains recover from stroke

April 6, 2018 by Bob Yirka, Medical Xpress report

A team of researchers from several institutions in Japan has found that a certain drug in conjunction with physical therapy has resulted in improved recovery from a stroke in mice and monkeys. In their paper published in the journal Science, the group describes their study of the impact of the drug on mice and monkeys and what they found. Simon Rumpel with the University Medical Center of the Johannes Gutenberg University Mainz in Germany offers a Perspectives piece on the work done by the team in the same issue, and also offers an outline on other therapies being developed to treat stroke victims.

A stroke occurs when the brain is damaged by lack of oxygen, either due to blockage or bursting of a blood vessel. The brain is unable to repair dead nerve cells, but some degree of function can be restored through physical therapy, which results in rewiring unharmed parts of the brain. But rewiring can only do so much. Thus, scientists continue to look for better therapies to help . In this new effort, the researchers have found a that promotes brain rewiring, resulting in improved recovery of motor skills.

Prior research has shown that a protein called CRMP2-binding compound is involved in rewiring the brain. The researchers wondered if it might be possible to introduce a drug into the brain that would bind with CRMP2 and help it do its rewiring job better. Prior research had suggested that a drug called edonerpic maleate might do just that.

Before an induced stroke, all animals smoothly performed both tasks, and they used precision grip in the vertical-slit task. Credit: H. Abe et al., Science (2018)

To test the drug, the researchers induced strokes in test and then gave them a dose of the drug a day later. Then, they put the rodents through physical therapy, testing them periodically to see how well motor function was being restored. They report significant improvements over mice administered a control drug. They note further that it was not enough just to give the mice the drug; the rodents still required for motor improvement. Pleased with their results, the researchers conducted the same round of tests with monkeys and report similar results. They are now making plans for a clinical trial, as the drug has already been proven safe for use in humans.

Administering edonerpic significantly affected the recovery of time to retrieve items, compared with the control group, for both near and far locations. Credit: H. Abe et al., Science (2018)

Administering edonerpic significantly affected the recovery of time to retrieve items, compared with the control group, for both near and far locations. Credit: H. Abe et al., Science (2018)

Explore further: Experimental therapy could boost stroke recovery

More information: Hiroki Abe et al. CRMP2-binding compound, edonerpic maleate, accelerates motor function recovery from brain damage, Science (2018). DOI: 10.1126/science.aao2300

Abstract
Brain damage such as stroke is a devastating neurological condition that may severely compromise patient quality of life. No effective medication-mediated intervention to accelerate rehabilitation has been established. We found that a small compound, edonerpic maleate, facilitated experience-driven synaptic glutamate AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic-acid) receptor delivery and resulted in the acceleration of motor function recovery after motor cortex cryoinjury in mice in a training-dependent manner through cortical reorganization. Edonerpic bound to collapsin-response-mediator-protein 2 (CRMP2) and failed to augment recovery in CRMP2-deficient mice. Edonerpic maleate enhanced motor function recovery from internal capsule hemorrhage in nonhuman primates. Thus, edonerpic maleate, a neural plasticity enhancer, could be a clinically potent small compound with which to accelerate rehabilitation after brain damage.

Related Stories

Experimental therapy could boost stroke recovery

February 1, 2018
An experimental therapy being tested by University of Alberta scientists that targets the spinal cord may one day be key to spurring on enhanced recovery for stroke victims.

Ketamine found to reduce bursting in brain area reducing depression quickly

February 15, 2018
A team of researchers at Zhejiang University in China has found that the drug ketamine reduces neuronal bursting in the lateral habenula (LHb) brain region, reducing symptoms of depression in rodent models. In their paper ...

New drug limits and then repairs brain damage in stroke

November 25, 2016
Researchers at The University of Manchester have discovered that a potential new drug reduces the number of brain cells destroyed by stroke and then helps to repair the damage.

Compound found to improve brain structure development of mice with Down syndrome

September 6, 2017
(Medical Xpress)—A team with members from several institutions in Japan has found a compound that reduces the impact of Down syndrome in mice. In their paper published in Proceedings of the National Academy of Sciences, ...

A nanoparticle inhalant for treating heart disease

January 18, 2018
A team of researchers from Italy and Germany has developed a nanoparticle inhalant for treating people suffering from heart disease. In their paper published in the journal Science Translational Medicine, the group describes ...

A quick jab could reduce stroke damage

September 20, 2017
A Perth treatment could significantly reduce the damage done to brain cells following a stroke.

Recommended for you

A peek into the interplay between sleep and wakefulness

July 20, 2018
Sleep is an autonomic process and is not always under our direct, voluntary control. Awake or asleep, we are basically under the regulation of two biological processes: sleep homeostasis, commonly known as 'sleep pressure', ...

Paralyzed mice with spinal cord injury made to walk again

July 19, 2018
Most people with spinal cord injury are paralyzed from the injury site down, even when the cord isn't completely severed. Why don't the spared portions of the spinal cord keep working? Researchers at Boston Children's Hospital ...

Neural inflammation plays critical role in stress-induced depression

July 19, 2018
A group of Japanese researchers has discovered that neural inflammation caused by the innate immune system plays an unexpectedly important role in stress-induced depression. This insight could potentially lead to the development ...

Scientists uncover the role of a protein in production and survival of myelin-forming cells

July 19, 2018
The nervous system is a complex organ that relies on a variety of biological players to ensure daily function of the human body. Myelin—a membrane produced by specialized glial cells—plays a critical role in protecting ...

Understanding the neuroscience of binge drinking

July 19, 2018
A new study from researchers at Columbia University Irving Medical Center found that binge drinking impairs working memory in the adolescent brain. The study, in mice, explains why teenagers who binge drink are 15 times more ...

Neurons can carry more than one signal at a time

July 18, 2018
Back in the early days of telecommunications, engineers devised a clever way to send multiple telephone calls through a single wire at the same time. Called time-division multiplexing, this technique rapidly switches between ...

1 comment

Adjust slider to filter visible comments by rank

Display comments: newest first

moranity
not rated yet Apr 07, 2018
my mouse/monkey hybrid is overjoyed at this news

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.