Mixed progress on drug resistance in A. baumannii infections in children

May 2, 2018, Center for Disease Dynamics, Economics & Policy

In the first national study of the prevalence of antibiotic-resistant Acinetobacter baumannii infections in children across the US, researchers from Center for Disease Dynamics, Economics, & Policy (CDDEP) in Washington, DC and Rush University in Chicago, IL examined national and regional trends of antibiotic resistance in clinical specimens over a 13-year period. While there was an overall increase between 1999 and 2012 in the proportion of isolates of A. baumannii that were resistant to cephalosporin and carbapenem, the authors noted a slight decline after a peak in 2008. The decrease may be attributable to a combination of antibiotic stewardship guidelines released in 2007 and infection control guidance specifically designed to combat multi-drug resistant A. baumannii in healthcare settings.

Infections caused by drug-susceptible A. baumannii are difficult to treat and the emergence of resistance has made treatment even more challenging. Highly resistant A. baumannii infections are increasingly being reported worldwide.

The study found that the crude proportion of cephalosporin-resistant A. baumannii increased from 13.2% in 1999 to 23.4% in 2012, whereas the proportion of carbapenem-resistant A. baumannii increased from 0.6% in 1999 to 6.1% in 2012. From 1999 to 2012, the proportion of cephalosporin-resistant and carbapenem-resistant A. baumannii increased each year by 3% and 8%, respectively; however, after 2008, a downward trend was observed, but resistance remained higher than was observed in 1999.

"Acinetobacter are bacteria known to cause serious infections that are notoriously difficult to treat because of growing ," according to Dr. Latania K. Logan of Rush University Medical Center. "The bacteria survive for long periods in the environment. Further studies are needed to assess the most effective prevention strategies in children, who are particularly vulnerable to A. baumannii."

"It is encouraging to see a downtrend after 2008, but we need to continue to monitor trends," said study co-author Dr. Sumanth Gandra of CDDEP. "The lack of new drugs to treat Acinetobacter remains a concern," he said.

Explore further: New resistance mechanism in the often multidrug resistant pathogen Acinetobacter baumannii

More information: Latania K Logan et al, Acinetobacter baumannii Resistance Trends in Children in the United States, 1999–2012, Journal of the Pediatric Infectious Diseases Society (2018). DOI: 10.1093/jpids/piy018

Related Stories

New resistance mechanism in the often multidrug resistant pathogen Acinetobacter baumannii

April 30, 2018
A team of Australian and Portuguese investigators has discovered yet another resistance mechanism in the pathogen, Acinetobacter baumannii, in this case, one that blocks the critical antibiotic-of-last-resort, colistin. A. ...

Efforts needed to stop the spread of carbapenem-resistant Acinetobacter baumannii

December 14, 2016
ECDC's latest risk assessment highlights the need of increased efforts to face this significant threat to patients and healthcare systems in all EU/EEA countries and outlines options to reduce risks through clinical management, ...

Communication key to preventing spread of drug-resistant bacteria

September 20, 2017
Communication breakdowns between care facilities can pave the way for outbreaks of infection, according to research on the spread of an extensively drug-resistant bacterium.

Serious, highly drug-resistant infections increasing among US children

November 17, 2016
Highly drug-resistant infections are on the rise among U.S. children, reports a new study published in the Journal of the Pediatric Infectious Diseases Society. Researchers found increasing rates of antibiotic resistance ...

Research project on dangerous hospital germ extended

March 8, 2018
Cases of antibiotic-resistant bacteria in hospitals have increased dramatically in recent years, and the health system faces tremendous problems as a result. Alongside Staphylococcus aureus (MRSA) and Klebsiella pneumonia, ...

Recommended for you

Tibetan sheep highly susceptible to human plague, originates from marmots

August 16, 2018
In the Qinghai-Tibet plateau, one of the region's highest risk areas for human plague, Himalayan marmots are the primary carriers of the infectious bacterium Y. pestis. Y. pestis infection can be transmitted to humans and ...

Autoimmunity plays role in development of COPD, study finds

August 16, 2018
Autoimmunity plays a role in the development of chronic obstructive pulmonary disease (COPD), according to a study led by Georgia State University and Vanderbilt University Medical Center that analyzed human genome information ...

Scientists identify nearly 200 potential tuberculosis drug targets

August 16, 2018
Tuberculosis is one of the top 10 causes of death worldwide. Nearly 2 million people die every year from this infectious disease, and an estimated 2 billion people are chronically infected. The only vaccine, developed almost ...

Reliable point-of-care blood test can help prevent toxoplasmosis

August 16, 2018
A recent study, performed in Chicago and Rabat, Morocco, found that a novel finger-prick test for infection with the parasite Toxoplasma gondii during pregnancy—and many other potential applications—is 100 percent sensitive ...

First mouse model to mimic lung disease could speed discovery of more effective treatments

August 16, 2018
The biggest hurdle to finding effective therapies for idiopathic pulmonary fibrosis (IPF) – a life-threatening condition in which the lungs become scarred and breathing is increasingly difficult – has been the inability ...

Anticancer drug offers potential alternative to transplant for patients with liver failure

August 15, 2018
Patients suffering sudden liver failure could in the future benefit from a new treatment that could reduce the need for transplants, research published today shows.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.