Generic options provide limited savings for expensive drugs

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Generic drug options did not reduce prices paid for the cancer therapy imatinib (Gleevec), according to a Health Affairs study released today in its May issue.

After nearly two years of the price for a month of treatment dropped by only 10 percent, according to authors from Vanderbilt University School of Medicine (VUSM) and University of North Carolina at Chapel Hill.

"Most estimates of price reductions due to generic entry assume will drop by as much as 80 percent," said senior author Stacie Dusetzina, Ph.D., associate professor of Health Policy at VUSM. "Obviously we aren't even close to that mark."

Not only are prices remaining high during that period, doctors were initially slow to prescribe the generic treatment, she said.

Gleevec, the poster child for effective cancer therapies, became available in 2001 and changed chronic myeloid leukemia from a condition with a short life expectancy into a manageable chronic disease.

Because patients typically take Gleevec every day for the rest of their lives, costs of treatment can be a significant burden.

It was priced at nearly $4,000 per bottle when it came on the market in 2001 and that price escalated to nearly $10,000 per bottle by 2015, before a generic competitor entered the market.

But prices remained high even two years after a generic option was available.

"Patients and providers have all looked forward to generic entry, expecting major price reductions," Dusetzina said. "Unfortunately, we don't see prices drop as quickly and as low as we would hope when generics are available."

Dusetzina and first author Ashley Cole, doctoral candidate at the University of North Carolina at Chapel Hill, focused specifically on generic price competition for the specialty Gleevec in their Health Affairs study, "Generic Price Competition For Specialty Drugs: Too Little, Too Late?"

The authors said the Gleevec case demonstrates several potential barriers to effective generic price competition, including shifts in prescribing toward more expensive brand-name treatments and smaller-than-expected price reductions.

Twenty-four percent of imatinib (Gleevec) prescriptions claims were for "dispense as written," according to the authors. This suggests that patients or providers specifically wanted to stay on the branded drug instead of switching to the generic.

"The more than doubling of the drug price over time and the lack of price reductions observed with nearly two years of generic drug competition is concerning," said Dusetzina, also the Ingram Associate Professor of Cancer Research.

"It begs the question whether we can rely on generic entry as a primary approach to address drug pricing for high-priced specialty medications," she said. "We need robust to move prices in this space."

Journal information: Health Affairs
Citation: Generic options provide limited savings for expensive drugs (2018, May 7) retrieved 18 March 2024 from https://medicalxpress.com/news/2018-05-options-limited-expensive-drugs.html
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