Biomarker panel may improve lung cancer risk assessment

August 6, 2018

(HealthDay)—Biomarker-based risk profiling has the potential to improve lung cancer risk assessment, according to a study published online July 12 in JAMA Oncology.

Florence Guida, Ph.D., from the International Agency for Research on Cancer in Lyon, France, and colleagues used samples from 108 ever-smoking patients with lung cancer diagnosed within a year of blood collection and samples from 216 smoking-matched controls to develop a lung cancer risk prediction model. The authors based the model on a panel of selected circulating protein biomarkers (cancer antigen 125 [CA125], carcinoembryonic antigen [CEA], cytokeratin-19 fragment [CYFRA 21-1], and the precursor form of surfactant protein B [Pro-SFTPB]) and compared its performance to a traditional risk prediction model and current U.S. screening criteria. The score was validated blindly using absolute risk estimates among 63 ever-smoking patients with lung cancer diagnosed within one year after blood collection and 90 matched controls from two large European population-based cohorts.

The researchers found that the integrated risk prediction model combining with the biomarker score yielded an area under the curve of 0.83 versus 0.73 for a model based on smoking exposure alone. With an overall specificity of 0.83, based on the U.S. Preventive Services Task Force screening criteria, the sensitivity of the integrated risk prediction (biomarker) model was 0.63 versus 0.43 for the smoking model. Conversely, with an overall sensitivity of 0.42, the integrated risk prediction model yielded a specificity of 0.95 compared with 0.86 for the smoking .

"This study provided a proof of principle in showing that a panel of circulating may improve lung risk assessment and may be used to define eligibility for computed tomography screening," the authors write.

The study was funded in part by 3M.

Explore further: Study shows biomarker panel boosts lung cancer risk assessment for smokers

More information: Abstract/Full Text (subscription or payment may be required)

Related Stories

Study shows biomarker panel boosts lung cancer risk assessment for smokers

July 12, 2018
A four-protein biomarker blood test improves lung cancer risk assessment over existing guidelines that rely solely upon smoking history, capturing risk for people who have ever smoked, not only for heavy smokers, an international ...

Researchers identify the most accurate risk prediction models for selecting whom to screen for lung cancer

May 15, 2018
Four risk prediction models have been shown to be most accurate for selecting the highest risk ever-smokers for lung cancer screening. Researchers suggest that this data can be used to inform future lung cancer screening ...

Risk-based lung cancer screening may save more lives than current USPSTF guidelines

January 2, 2018
Lung cancer screening based on individual risk has the potential to save more lives than current recommendations by the U.S. Preventive Services Task Force (USPSTF). The findings are published in Annals of Internal Medicine.

Risk-based CT screening may reduce deaths from lung cancer

January 1, 2018
Compared to National Lung Screening Trial criteria, targeting screening those at highest risk from lung cancer mortality using a risk prediction tool may improve efficiency in terms of greater reduction in mortality from ...

Model more accurately predicts lung cancer risk

February 22, 2013
(HealthDay)—A new model to predict lung cancer risk is more accurate than previous criteria, according to a study published in the Feb. 21 issue of the New England Journal of Medicine.

Active surveillance of lung subsolid nodules reduces unnecessary surgery and overtreatment

July 17, 2018
Subsolid nodules (SSN) can be considered a biomarker of lung cancer risk and should be managed with long-term active surveillance. Conservative management of SSN will reduce unnecessary surgery and overtreatment in patients ...

Recommended for you

Two ways cancer resists treatment are actually connected, with one activating the other

December 18, 2018
Drugs that target BRAF and MEK in cancer have shown promise in treating a subset of melanoma that carries a mutation in the BRAF gene, but drug resistance usually emerges, reversing the benefit of these drugs and limiting ...

HPV discovery raises hope for new cervical cancer treatments

December 18, 2018
Researchers at the University of Virginia School of Medicine have made a discovery about human papillomavirus (HPV) that could lead to new treatments for cervical cancer and other cancers caused by the virus.

Vaccine, checkpoint drugs combination shows promise for pancreatic cancers

December 18, 2018
Researchers at the Johns Hopkins Kimmel Cancer Center discovered a combination of a cancer vaccine with two checkpoint drugs reduced pancreatic cancer tumors in mice, demonstrating a possible pathway for treatment of people ...

Researchers identify ways breast cancer avoids immune system detection

December 18, 2018
Recent breakthroughs in immunotherapy are making a huge difference in treating some forms of cancer, especially metastatic cancer. But breast cancer has proven a tricky foe for this new therapy, and an interdisciplinary team ...

Metal chemotherapy drugs boost the impact of immunotherapy in cancer

December 18, 2018
Due to their powerful tumour-killing effect, metal-based chemotherapies are frequently used in cancer treatment. However, it was hitherto assumed that they damaged the immune system, because of their cytotoxic (cell-damaging) ...

10-year follow-up after negative colonoscopies linked to lower colorectal cancer risk

December 17, 2018
Ten years after a negative colonoscopy, Kaiser Permanente members had 46 percent lower risk of being diagnosed with and were 88 percent less likely to die from colorectal cancer compared with those who did not undergo colorectal ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.