Asthma's androgen connection

Credit: CC0 Public Domain

Women are more prone to developing asthma, particularly more severe types of asthma, compared to men. Studies have shown that the sex hormones, estrogen and testosterone, influence the mechanisms driving airway inflammation in animal models of asthma.

However, it has remained unclear how estrogen and testosterone affect pathways that increase the number of eosinophils and neutrophils, specific types of , entering the lung in .

In the current issue of the Journal of Immunology, Dawn C. Newcomb, Ph.D., and colleagues reportthat testosterone decreased type 2, eosinophilic and IL-17A, neutrophilic responses, whereas ovarian hormones increased these responses in a mouse model of .

These findings provide a possible reason why the prevalence of asthma is higher in women and suggest that testosterone derivatives have a potential role in being used to treat patients with more severe types of asthma.

More information: Hubaida Fuseini et al. Testosterone Decreases House Dust Mite–Induced Type 2 and IL-17A–Mediated Airway Inflammation, The Journal of Immunology (2018). DOI: 10.4049/jimmunol.1800293

Journal information: Journal of Immunology

Citation: Asthma's androgen connection (2018, October 17) retrieved 30 September 2023 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Why do more women have asthma than men? Blame hormones


Feedback to editors