Tiny DNA modification has big impact on deadly tumors

Tiny DNA modification has big impact on deadly tumors
Credit: stock.adobe.com

A simple modification of a DNA base in small areas of the genome may explain why glioblastoma tumors are so deadly, researchers at Yale and the University of California-San Diego report Nov. 1 in the journal Cell.

Glioblastomas are particularly virulent tumors, with survival rates of only about three to six months. A major culprit is the existence of a group of special tumor cells that are highly resistant to standard therapies. The modification of the A base in DNA, one of four genetic letters which form the structural backbone of DNA, was found in large numbers in tumors, especially stem , researchers report. They also found the modification affects growth of human gliomas engrafted into mice brains.

This base modification was seen in earliest stage in embryo development and appears crucial to development of the fetus, but disappears later in adult life, the researchers note.

"But in the case of glioblastomas, cancer appears to hijack this mechanism," said Andrew Xiao, associate professor of genetics at the Yale Stem Cell Center, researcher with the Yale Cancer Center and co-corresponding author of the paper along with Jeremy Rich at Moores Cancer Center at UC-San Diego Health.

The several-hundredfold increase of modified A base in tumors—barely detectable in normal brain tissues—means the base may make an attractive target for new drug therapies, Xiao said.

The modification may also be found in other tumors as well and may suggest new ways to treat now-incurable brain tumors, he said.

More information: Qi Xie et al. N-methyladenine DNA Modification in Glioblastoma, Cell (2018). DOI: 10.1016/j.cell.2018.10.006

Journal information: Cell
Provided by Yale University
Citation: Tiny DNA modification has big impact on deadly tumors (2018, November 2) retrieved 3 March 2024 from https://medicalxpress.com/news/2018-11-tiny-dna-modification-big-impact.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

A breakthrough for understanding glioblastoma—origin cells for deadly brain tumors identified


Feedback to editors